Cystic Fibrosis Clinical Trial
Official title:
Detection of Pulmonary Colonization in Cystic Fibrosis Patients
This experiment is designed to test the effectiveness of a new electronic nose device, which
allows a non-invasive breath test for markers of lower respiratory tract infection, which
may predict the probability of bacterial organisms in the lower respiratory tract. It
consists of:
- A breath collection apparatus for collection of volatile organic compounds in breath
onto a sorbent trap and Tedlar bag, as well as for the collection of a separate sample
of room air.
- Analysis of the volatile organic compounds in breath and room air by short acoustic
wave/gas chromatography.
- Interpretation of the volatile organic compounds with a proprietary algorithm in order
to predict the probability of lower respiratory tract colonization and infection.
This study will test the hypothesis that the investigators can identify the presence of
Pseudomonas aeruginosa by sampling the "head space" above culture media of sputum provided
by patients with cystic fibrosis. This study will test the additional hypothesis that the
investigators can identify the presence of Pseudomonas aeruginosa by sampling exhaled breath
from the patient providing the sputum.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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