Cystic Fibrosis Clinical Trial
Official title:
Does a Nasal Instillation of Vardenafil Normalize the Nasal Potential Difference in Cystic Fibrosis Patients Homozygous for the F508del Mutation? A Randomized, Double Blind, Placebo-controlled Study.
The purpose of this study is to investigate the effect of a nasal instillation of Vardenafil on nasal potential difference in cystic fibrosis patients homozygous for the F508del mutation
CFTR protein has been shown to be an ohmic, small conductance channel regulated by cAMP
intracellular levels that are balanced by degradation through cyclic nucleotide
phosphodiesterases (PDE). Several families of PDEs with varying selectivities for cAMP and/or
cGMP have been identified.PDE5 is highly specific for cGMP and is involved in the regulation
of the intracellular concentration of cGMP in various tissues. Recently, it has been shown,
in a preclinical model of transgenic mice, that pharmacological doses of sildenafil and
vardenafil, two clinically approved PDE5 inhibitors, stimulate chloride transport activity of
the mutant F508del-protein (Lubamba et al, 2008); this parameter has been assessed by means
of the nasal potential difference (NPD). An increasing effect of sildenafil on the expression
of F508del-CFTR protein (Dormer et al,2005) was originally reported in nasal epithelial cells
harvested from patients with cystic fibrosis and cultured on impermeable supports, a
configuration that allows interaction of drugs with the apical side of epithelia.
This study aims at investigating the effect of a single local administration of vardenafil on
NPD measurements in CF patients homozygous for the F508del mutation.
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