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One Year Glargine Treatment in CFRD Children and Adolescents

Cystic Fibrosis Clinical Trial

Official title:
One-Year Glargine-Treatment Can Ameliorate Clinical Features in Cystic Fibrosis Children and Adolescents With Glucose Derangements

Clinical Trial Summary

Glargine treatment can improve the clinical features in Cystic Fibrosis patients affected by glucose derangements

Clinical Trial Description

To evaluate the effect of glargine treatment on BMI, lung function, acute pulmonary infections and HbA1c in cystic fibrosis (CF) patients with different glucose derangements, eighty-seven patients were screened for glucose derangements with fasting hyperglycaemia or abnormalities at the oral glucose tolerance test. They were classified on the basis of a “gluco-score” ranging 0-5. Patients with gluco-score > 1 were treated with glargine. We report on the results of the first 20 patients who completed 12 months of treatment. BMI z-score, forced expiratory volume in the first second (FEV1), number of acute lung infections in the previous year and HbA1c were the study outcomes. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00483769
Study type Interventional
Source Federico II University
Contact
Status Completed
Phase Phase 4
Start date February 2006
Completion date January 2007
View Details
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