The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS)

Cyclic Vomiting Syndrome Clinical Trial

Official title:

Co-Enzyme Q10, L-Carnitine and Amitriptyline Usage in Cyclic Vomiting Syndrome (CVS): A Research Study

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT00728104
• Other study ID #: 090
• Status: Withdrawn
• Phase: N/A
• First received: July 31, 2008
• Last updated: February 3, 2017
• Start date: October 2007
• Est. completion date: January 2017

Study information

• Verified date: February 2017
• Source: Medical College of Wisconsin
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a study with the principle goal being to learn about the use of L-Carnitine and CoQ10, two vitamin supplements that are currently being used to treat Cyclic Vomiting Syndrome, largely initiated by parents. We want to learn how effective these supplements are compared to standard treatment, at what dose, and what onset of action in order to initiate future prospective study on these supplements.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: January 2017
• Est. primary completion date: January 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• 3 discrete episodes of vomiting

• normal health between episodes

• stereotypical clinical pattern

• no abnormal test results to account for vomiting (see exclusion criteria)

Exclusion Criteria:

• abnormal UGI with small bowel follow-through revealing an anatomic anomaly, inflammatory or obstructive

• Significantly abnormal endoscopic biopsies (moderate to severe esophagitis, H. pylori)

• Abnormal abdominal ultrasound revealing hydronephrosis, cholelithiasis, pancreatitis

• Positive screening for endocrine disorder (diabetic ketoacidosis, Addison's)

• Positive screening for inborn errors of metabolism (hypoglycemia, lactic acidosis, hyperammonemia, organic acidemia, amino aciduria, elevated beta-ALA, porphobilinogen)

Related Conditions & MeSH terms

• Cyclic Vomiting Syndrome
• Syndrome
• Vomiting

Locations

Country	Name	City	State
United States	Children's Hospital of Wisconsin	Milwaukee	Wisconsin

Sponsors (2)

Lead Sponsor	Collaborator
Medical College of Wisconsin	Children's Hospital Los Angeles

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	How two vitamin supplements are being used to treat cyclic vomiting syndrome		Two years
Secondary	How effective these supplements appear to be compared to standard treatment		Two years

External Links

•   Cyclic Vomiting Syndrome Association