Cushing Syndrome Clinical Trial
Official title:
Skin Microcirculation Evaluation With Nailfold Capillaroscopy in Cushing's Syndrome Patients
This cross-sectional, single-center study will assess the microvascular function using a nailfold video-capillaroscopy in patients with endogenous Cushing syndrome.
Status | Not yet recruiting |
Enrollment | 200 |
Est. completion date | January 15, 2021 |
Est. primary completion date | December 31, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Male and female patients diagnosed as Cushing syndrome (CS) caused by ACTH-producing pituitary adenoma or cortisol producing adrenal adenoma - Age between 18 and 70 years Exclusion Criteria: - Chronic glucocorticoid use - CS caused by ectopic ACTH producing tumors - CS caused by adrenocortical carcinoma - Pseudo CS - Patients with Raynaud phenomenon - Patients with collagen tissue disease - Patients who use drugs that affect the metabolism of fibrinolysis (such as oral contraceptives) - Employees at work at risk of microtrauma (such as gardeners, farmers) - Skin diseases with nail fold involvement (such as dermatitis, psoriasis) |
Country | Name | City | State |
---|---|---|---|
Turkey | Marmara University Medical School Section of Endocrinology and Metabolism | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Marmara University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Nailfold capillary number of tortuous loops | Nailfold capillary area changes | 6 months | |
Primary | Nailfold capillary area number of meandering capillaries | Nailfold capillary area changes | 6 months | |
Primary | Nailfold capillary avascular areas | Nailfold capillary area changes | 6 months | |
Secondary | Correlation between nailfold capillary number of tortuous loops and presence of diabetes | Independent risk factors that affected nailfold capillaroscopy images | 6 months | |
Secondary | Correlation between nailfold capillary number of tortuous loop with urine free cortisol levels | Presence and severity of hypercortisolism as an independent risk factor | 6 months |
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