Cushing's Syndrome Clinical Trial
OBJECTIVES: I. Evaluate whether chronic hypercortisolemia is specifically toxic to
hippocampal cells and causes structural reduction of hippocampal volume in patients with
Cushing's syndrome.
II. Determine whether reduced hippocampal volume is associated with specific memory
dysfunction.
III. Examine the relationships of adrenal androgen to hippocampal volume and memory
dysfunction.
IV. Examine the reversibility of hippocampal structural changes and cognitive dysfunction
after cortisol levels are normalized.
PROTOCOL OUTLINE: Patients undergo a psychiatric evaluation for mood and cognition during
confirmation of diagnosis. Neuropsychologic exams include pencil and paper test and a
cognitive assessment.
Endocrine studies include dexamethasone and corticotropin-releasing hormone stimulation
tests. The hippocampal complex volume is assessed with coronal magnetic resonance imaging.
There is a follow-up 1 year after the initiation of treatment.
;
Primary Purpose: Screening
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