Cubital Tunnel Syndrome Clinical Trial
Official title:
Cubital Tunnel Syndrome and Diffusion Tensor Magnetic Resonance Imaging: A Proof of Concept Study
Cubital Tunnel Syndrome (CTS) results from compression of the ulnar nerve at the elbow
(colloquially termed the "funny bone"). CTS affects up to 6% of the population and 6000
patients undergo surgery annually in the UK. Surgery is the only proven treatment for CTS,
although up to 30% of patients do not improve. Therefore, there is a pressing need to develop
a reliable test to diagnose CTS to improve the selection of patients for surgery.
New techniques in the field of magnetic resonance imaging (MRI) allow the visualisation of
nerve structure and function. Diffusion tensor MRI, also known as diffusion tensor imaging
(DTI), can diagnose CTS with superior diagnostic accuracy and could enable the reliable
diagnostic of CTS, improving the selection of patients for surgery.
The study will include healthy volunteers (to refine the scanning sequence) and patients
undergoing surgery for CTS. Patients will be scanned preoperatively and postoperatively using
cutting-edge diffusion MRI techniques. The primary outcome will be change in the MRI-derived
diffusion metrics following surgery. Secondary outcomes will consider how MRI relates to
patient-reported outcomes and conventional clinical tests (ultrasound and nerve conduction
studies).
Leeds is the ideal location for this research because a) Leeds institutions are the most
highly cited organisations in musculoskeletal research, b) Leeds houses the National Centre
for Hyperpolarized MRI and a state-of-the-art MRI scanner, and c) Leeds is an internationally
recognised centre of excellence for complex upper limb surgery.
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