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Three Induction Treatments on Cryptococcal Meningitis — TITOC  

HIV/AIDS Clinical Trial

Official title:
The Effect and Safety of Three Initial Introduction Treatments on HIV-infected Patients With Cryptococcal Meningitis: A Multi-center, Random and Prospective Study

Clinical Trial Summary

Three induction treatment strategies [ voriconazole +5FC vs. amphotericin deoxycholate (0.4-0.5 mg/kg/d)+5FC vs. amphotericin deoxycholate (0.7-1.0 mg/kg/d)+5FC ] for HIV-infected patients with cryptococcal meningitis were compared.

Clinical Trial Description

HIV-associated cryptococcal meningitis were randomly allocated into three induction treatment as follow: 1) 14 days of voriconazole 200mg bid +5FC, 2) 28 days of amphotericin deoxycholate (0.4-0.5 mg/kg/d) +5FC ; 3）14 days of deoxycholate (0.7-1 mg/kg/d) +5FC). After induction treatment were finished, all groups switched into fluconazole(400mg/d) for two-month consolidation treatment. 14-day early fungicidal rate, 90-day mortality, side effects , and tolerances were compared between three groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04072640
Study type Interventional
Source First Affiliated Hospital of Zhejiang University
Contact
Status Active, not recruiting
Phase Early Phase 1
Start date January 25, 2021
Completion date December 1, 2022
View Details
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