Cold Therapy in the Treatment of Exercise-induced Muscle Damage

Cryotherapy Effect Clinical Trial

Official title:

Effects of Different Cold Therapy Modalities on Muscular Recovery and Inflammatory Responses Following Exercise-induced Muscle Damage in Healthy Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02341612
• Other study ID #: CEP/FS-UnB 234/13
• Status: Completed
• Phase: N/A
• First received: December 16, 2014
• Last updated: January 16, 2015
• Start date: December 2013
• Est. completion date: August 2014

Study information

• Verified date: January 2015
• Source: University of Brasilia
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

Subjects were randomly placed in five groups: (1) single exposure at 5°C in cold water immersion, (2) single exposure at 15°C in cold water immersion, (3) multiple exposures at 10°C in cold water immersion, (4) whole body cryotherapy (WBC) at 110°C and (5) passive recovery (control group). The single exposure groups performed cold water immersion immediately after exercise-induced muscle damage (EIMD) for 20 minutes. The multiple exposures group performed cold water immersion immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes. The WBC group remained in the cabin immediately after EIMD for 3 min. The control group was not exposed to treatment after the EIMD protocol. The subjects were asked to visit the laboratory on seven occasions. The first visit was the familiarization of the subjects with experimental procedures and their anthropometric assessment. One week after familiarization, on visit two, volunteers performed the exercise-induced muscle damage (EIMD) protocol and they were allocated to one of experimental groups. Indirect markers of muscle damage and inflammatory responses were evaluated at baseline (pre), immediately post, 24h, 48h, 72h, 96h, and 168h following the EIMD protocol by measuring anterior thigh muscle swelling, isometric knee extensors peak torque, knee extensors muscle soreness, countermovement vertical jump and blood sample analyzes.

Description:

To avoid circadian influences, subjects were asked to visit the laboratory always at the same time of day. Volunteers were asked to not perform any vigorous physical activities or unaccustomed exercise during the experiment period. In addition, they were instructed not to intake medications or supplements during the study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 65
• Est. completion date: August 2014
• Est. primary completion date: August 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• College students were eligible for inclusion.

Exclusion Criteria:

• Exclusion criteria included a history of eccentric quadriceps exercise in the past 3 months

• A history of quadriceps muscle tear

• Neurological disease involving the lower limbs

• Current lower-limb musculoskeletal injury and thigh skinfold thickness >20 mm..

• Participants with potential vascular problems which cold therapy is contraindicated (eg, diagnoses of diabetes or Raynaud's disease) were also excluded

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Cryotherapy Effect

Intervention

Other:
• single exposure at 5°C in CWI
The subjects of this group performed cold water immersion immediately after exercise-induced muscle damage (EIMD) a single exposure at 5°C for 20 minutes.
• single exposure at 15°C in CWI
The subjects of this group performed CWI immediately after EIMD a single exposure at 15°C for 20 minutes.
• multiple exposures at 10°C in CWI
The subjects of this group performed CWI immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes.
• whole body cryotherapy (WBC)
The whole body criotherapy (WBC) group remained in the cabin immediately after EIMD for 3 minutes.
• passive recovery
The control group was exposed to treatment after the EIMD protocol.

Locations

Country	Name	City	State
Brazil	University of Brasília	Brasília	DF

Sponsors (2)

Lead Sponsor	Collaborator
University of Brasilia	Conselho Nacional de Desenvolvimento Científico e Tecnológico

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change of knee extensors muscle maximal isometric voluntary contraction during 168h post exercise-induced muscle damage (EIMD), assessed using isokinetic dynamometer		at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.	Yes
Secondary	Change of the anterior thigh muscle swelling during 168h post EIMD, assessed using ultrasound device		at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.	Yes
Secondary	Change of the knee extensors muscle soreness during 168h post EIMD, assessed using a Visual Analogue Scale		at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.	Yes
Secondary	Change of inflammatory response (Tumor Necrosis Factor-a, interleukin-6, interleukin-10, interleukin-1ß, interleukin-1ra) during 168h post EIMD, assessed by blood sample analyzes		at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.	Yes
Secondary	Change on the performance of countermovement vertical jump during 168h post EIMD, assessed using a force plate		at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.	Yes