Complex Regional Pain Syndromes Clinical Trial
Official title:
Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb
The purpose of this study is to determine whether application of low dose Delta9-Tetrahydrocannabinol can prevent the development of chronic pain in patients with acute CRPS.
Recent animal data suggest that the endocannabinoid system is a promising target in the
prevention of chronic pain. It has been shown that the endocannabinoid system modifies
excitatory and inhibitory currents in structures involved in the development of chronic pain
such as the amygdala.
CRPS is a neuropathic pain condition, which is known to become chronic in a significant
percentage. The study compares the effect of low dose Delta9-Tetrahydrocannabinol (90 days)
and placebo in acute CRPS. All patients will receive a standard treatment consisting of drug
therapy and physiotherapy.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double-Blind, Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04066933 -
Forms of Cervical Brachial Syndrome Treated With Plasma Concentrate Enriched for A2M
|
||
Completed |
NCT04597866 -
Treatment of Complex Regional Pain Syndrome, a Long-term Follow-up
|
||
Completed |
NCT04060875 -
Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
|
||
Not yet recruiting |
NCT06453447 -
Prednisone for CRPS in Distal Radius Fracture
|
N/A | |
Terminated |
NCT01954888 -
Impact of the Ultrasound-guided Approach on the Efficiency and Safety of the Stellate Ganglion Block in Chronic Pain
|
N/A | |
Terminated |
NCT00689585 -
Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS)
|
Phase 2 | |
Recruiting |
NCT05787119 -
Benefit of Augmented Reality Mirror Therapy in Addition to Conventional Management in Complex Regional Pain Syndrome of the Upper Extremity
|
N/A | |
Recruiting |
NCT05523934 -
Retrospective Analysis of capsaïcin Patch in Complex Regional Pain Syndrome
|
||
Recruiting |
NCT04732325 -
Sensory Testing of Multiple Forms of Spinal Cord Stimulation for Pain
|
N/A | |
Completed |
NCT03174249 -
Exposure Therapy Combined With Cortical Interventions for CRPS-II
|
N/A | |
Recruiting |
NCT06033456 -
Combining Stellate Ganglion and T2 and T3 Radiofrequency Ablation on Post-mastectomy Complex Regional Pain Syndrome
|
N/A | |
Recruiting |
NCT04144972 -
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
|
N/A | |
Completed |
NCT02490436 -
Novel Treatment Option for Neuropathic Pain
|
Phase 2 | |
Withdrawn |
NCT03316066 -
Comparison of Volumes of Local Anesthetics on the Efficiency and Safety of Stellate Ganglion Block for CRPS of the Arm
|
N/A | |
Recruiting |
NCT05491499 -
Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
|
||
Completed |
NCT03291197 -
Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome
|
Phase 4 | |
Recruiting |
NCT05034835 -
Impact of Compression Garments on Pain in Patients With Complex Regional Pain Syndrome of the Upper Limbs.
|
N/A | |
Completed |
NCT05696587 -
Physical and Psychological Changes in CRPS Patients Undergoing Multimodal Rehabilitation
|
N/A | |
Recruiting |
NCT02957240 -
Graded Motor Imagery for Women at Risk for Developing Type I CRPS Following Closed Treatment of Distal Radius Fractures
|
N/A | |
Terminated |
NCT00891397 -
Pregabalin Versus Placebo as an Add on for Complex Regional Pain Syndrome (CPRS) of the Upper Limb Managed by Stellate Ganglion Block (The PREGA Study)
|
N/A |