Critical Illness Clinical Trial
Official title:
Association of Gut Microbiota Diversity With Extended-spectrum Beta-lactamase Producing Enterobacteriales Fecal Carriage and Subsequent Infection in Intensive Care Unit: Microbe Study
Antimicrobial resistance is a major threat worldwide and extended-spectrum beta-lactamase producing Enterobacteriales (ESBL-E) are a leading cause because of their wide dissemination. Gut microbiota seems to be correlated with multi-drug resistant organism carriage. This study thus aims to analyse the correlation between gut microbiota, ESBL-E fecal carriage and subsequent infection.
The rising antimicrobial resistance has led to more than 33,000 deaths in Europe in 2015.
Among them, extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are the
most frequent in Europe and have disseminated both in the community and in healthcare
settings. Some studies have suggested that microbiota could be different between multi-drug
resistant organisms, with different relative abundances of some bacteria. One study focused
on ESBL-E fecal carriers, but in the community, with Bacteroides uniformis being more
abundant in ESBL-E non-carriers than carriers. As identification of species discriminating
between ESBL-E fecal carriers and non-carriers could pave the way for the design of ESBL-E
carriage eliminating probiotics, we aim to analyse the correlation between gut microbiota and
ESBL-E fecal carriage.
Moreover, mechanisms in the link between ESBL-E fecal carriage and subsequent ESBL-E
infection remain, so far, poorly understood and this study aims to provide a first insight in
the involvement of gut microbiota in the link between colonization and infection.
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