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NCT01796847 Clinical Trial

Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients

Critical Illness Clinical Trial

— GLUPTEN  

Official title:
Influence of PTEN on Glycemic Variability and Clinical Outcome in the Critically Ill Patient.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01796847
Other study ID # LAVPTEN
Secondary ID
Status Completed
Phase N/A
First received February 11, 2013
Last updated November 3, 2017
Start date December 2012
Est. completion date May 2015

Study information
Verified date November 2017
Source University of Roma La Sapienza
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood. The Phosphatase and Tensin homolog (PTEN) is known to influence glucose homeostasis by interfering in intracellular insulin signaling.

Aim of this study is to ascertain whether differential expression of PTEN in critically ill patients correlates with glycemic variability and clinical outcome.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date May 2015
Est. primary completion date December 2014
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- trauma

- provision informed consent

Exclusion Criteria:

- diabetes

- impaired fasting glucose levels

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Italy University of Rome La Sapienza, University Hospital Rome

Sponsors (1)
Lead Sponsor Collaborator
University of Roma La Sapienza

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary Length of ICU stay Day 1 up to day 28
Secondary Glycemic variability as expressed by standard deviation of the glycemia measurements Day 1 up to day 28
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