Clinical Trial Details
— Status: Active, not recruiting
Administrative data
| NCT number |
NCT06170307 |
| Other study ID # |
YXLL-KY-2023(136) |
| Secondary ID |
|
| Status |
Active, not recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
November 20, 2023 |
| Est. completion date |
July 20, 2024 |
Study information
| Verified date |
December 2023 |
| Source |
Qianfoshan Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
The goal of this observational study is to retrospectively analyze left atrial function in
mild to moderate COVID-19-recovered patients. The main questions it aims to answer are:
- Whether left atrial function is involved in patients with mild to moderate COVID-19
after recovery.
- What are the factors that may be associated with persistent heart-related symptoms
(including chest pain, chest tightness, palpitations, shortness of breath, or postural
tachycardia) in patients with mild to moderate COVID-19 ?
Participants will undergo transthoracic echocardiography to obtain conventional ultrasound
parameters, two-dimensional strain parameters will been obtained through software
post-processing, and general clinical data and laboratory test results will been obtained.
Description:
The included patients who recovered from COVID-19 infection and healthy people underwent
transthoracic echocardiography at the First Affiliated Hospital of Shandong First Medical
University from December 20, 2022 to January 20, 2023. Routine data and two-dimensional
strain parameters of transthoracic echocardiography of the study subjects were obtained:
1. The echocardiographic examination was performed using a Epiq 7C ultrasound machine, and
images were acquired with the patient in left lateral decubitus using a 3.5-5 MHz
transducer at a depth of 16 cm. ECG was recorded, and 3 consecutive cardiac cycles of
each view were recorded during quiet breathing at 50-80 frames/sec. All patients were
subjected to conventional transthoracic echocardiography & Speckle tracking
echocardiography (STE). All measurements were taken following the American Society of
Echocardiography (ASE) recommendations.
2. Left atrial strain analysis was obtained using automated speckle tracking software. The
regions of interest were generated automatically and Left atrial endocardial border was
manually adjusted when required. Left atrial phases definition and Left atrial strain
values were measured from the Left atrial longitudinal strain curve according to the
European Association of Cardiovascular Imaging (EACVI)/American society of
echocardiography (ASE) guidelines. Global LV systolic strain was evaluated, and the
software automatically traced the contour of the endocardium at apical three, four and
two-chamber views.
3. At the same time, the general clinical data, demographic characteristics,
electrocardiogram, chest CT results, troponin I (hsTnI) and brain natriol peptide levels
on the day of echocardiographic examination were obtained through the hospital
electronic medical record His system.
4. Clinical follow-up was performed 12-18 months after the echocardiographic examination by
phone and by electronic health record review. We recorded: 1) persistent cardiac
symptoms, 2) interval presentation to the emergency department or hospitalization with
cardiac symptoms, and 3) any major adverse cardiac event (myocardial infarction, stroke,
revascularization, or death).
