Effect of a Third COVID-19 Booster Among Health Care Workers

COVID-19 Vaccines Clinical Trial

Official title:

Effect of a Third COVID-19 Booster on COVID-19 Infection Rate and Return to Works During Fifth Wave COVID-19 Among Health Care Workers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05373459
• Other study ID #: Third COVID-19 booster
• Status: Completed
• Start date: May 16, 2022
• Est. completion date: December 31, 2022

Study information

• Verified date: February 2024
• Source: Hong Kong Sanatorium & Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A new wave of COVID-19 infections, mainly caused by the Omicron/ Delta variant, has been sweeping the globe since the start of 2022. In response, the administration of a third dose of COVID-19 vaccine was considered to address potential waning immunity over time and reduced effectiveness against the Omicron/ Delta variant. The pandemic also resulted in many infections among health care workers (HCWs) and their households. In this study, a retrospective analysis would perform on risk of COVID-19 infection and their outcome in relation to their COVID-19 vaccination history by using the data repository from one of the Hong Kong private hospitals.

HCWs were required to submit a standardized online self-declaration form for report of 1) demographic of the HCWs, 2) symptoms related history and 3) COVID-19 exposure history once they were COVID-19 confirmed by rapid antigen test against COVID-19 and/or polymerase chain reaction (PCR) test for COVID-19. Subsequent follow up such as contact tracing, COVID-19 PCR testing results of these HCWs and status of return to work were captured by the infection control team in a systematic manner.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 3167
• Est. completion date: December 31, 2022
• Est. primary completion date: December 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All full time staff members of the private hospital

Exclusion Criteria:

• History of COVID-19 before 2022

Related Conditions & MeSH terms

• COVID-19
• COVID-19 Vaccines

Intervention

Biological:
• Third COVID-19 booster
Third COVID-19 booster

Locations

Country	Name	City	State
Hong Kong	Hong Kong Sanatorium & Hospital	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Hong Kong Sanatorium & Hospital

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	COVID-19 Infection	Number of participants with COVID-19 infected	During 1 February - 31 March 2022
Primary	Number of days return to work after COVID-19 infection	Number of days return to work after COVID-19 infection	During 1 February - 31 March 2022