Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients?

Covid-19 Patients Clinical Trial

— TA/SARS-Cov2  

Official title:

Is Adipose Tissue a Reservoir for SARS-Cov2 Spread?

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04427878
• Other study ID #: 20-PP-15
• Status: Not yet recruiting
• Phase: N/A
• Start date: July 1, 2020
• Est. completion date: July 9, 2021

Study information

• Verified date: June 2020
• Source: Centre Hospitalier Universitaire de Nice
• Contact: Vanina OLIVERI, PM
• Phone: 0033 4 92 03 42 54
• Email: oliveri.v[@]chu-nice.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 5
• Est. completion date: July 9, 2021
• Est. primary completion date: July 9, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Male or female = 18 years old

• Patients testing positive for Covid19

• Patients affiliated to social security

• Signing of free and informed consent

Exclusion Criteria:

• Vulnerable persons (- minors,

• adults under guardianship or curatorship,

• pregnant women,

• persons deprived of their liberty,

• persons who do not master the French language)

Related Conditions & MeSH terms

• Covid-19 Patients

Intervention

Procedure:
• biopsies of subcutaneous adipose tissue
Two 4mm punch biopsies of subcutaneous abdominal or thight adipose tissue

Locations

Country	Name	City	State
France	CHU de Nice	Nice

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nice

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The presence of SARS-CoV2 in adipose tissue of Covid19 patients	RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection	Day 0
Secondary	The expression of inflammatory cytokines in adipose tissue of Covid19 patients	RT-qPCR for IL6	Day 0
Secondary	The expression of inflammatory cytokines in adipose tissue of Covid19 patients	RT-qPCR for IL1	Day 0
Secondary	The expression of inflammatory cytokines in adipose tissue of Covid19 patients	RT-qPCR for TNFa	Day 0