COVID Clinical Trial
Official title:
Efficacy of Ivermectin in COVID-19 : A Randomized Controlled Trial
NCT number | NCT04392713 |
Other study ID # | IVE-COV |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | April 15, 2020 |
Est. completion date | July 2020 |
It is a randomized controlled trial to assess the efficacy of Ivermectin in COVID-19. Patient recruited will be assigned to two groups one group will be given ivermectin with standard chloroquine regimen and the other group will be receiving chloroquine only. Out come will be recorded by documenting PCR reports at 48, 96 and 144 hours.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | July 2020 |
Est. primary completion date | July 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 15 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Provision of signed and dated informed consent form - Stated willingness to comply with all study procedures and availability for the duration of the study - Male or female, aged 15 to 65 years - In good general health with no or mild to moderate symptoms of Corona virus disease - PCR positive for SARS-Cov-2. - Ability to take oral medication and be willing to adhere to the drug intake regimen Exclusion Criteria: - Severe symptoms likely attributed to Cytokine Release Storm. - Malignant diseases, diabetes mellitus, chronic kidney disease and cirrhosis liver with CPT class B or C. |
Country | Name | City | State |
---|---|---|---|
Pakistan | Combined Military Hospital Lahore | Lahore | Punjab |
Lead Sponsor | Collaborator |
---|---|
Combined Military Hospital, Pakistan |
Pakistan,
Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020 Apr 3;178:104787. doi: 10.1016/j.antiviral.2020.104787. [Epub ahead of print] — View Citation
Simsek Yavuz S, Ünal S. Antiviral treatment of COVID-19. Turk J Med Sci. 2020 Apr 21;50(SI-1):611-619. doi: 10.3906/sag-2004-145. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Negative PCR | PCR will be done at 48, 96 and 144 hours | 144 hours | |
Secondary | Need for mechanical ventilation | All patients will be assessed for requirement of mechanical ventilation in both the groups | 4 weeks |
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