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NCT ID: NCT00914459 Active, not recruiting - Hemophilia A Clinical Trials

Study Evaluating Safety And Efficacy Of Moroctocog Alfa (AF-CC) In Previously Treated Hemophilia A Patients

Start date: December 2009
Phase: Phase 4
Study type: Interventional

The study will be investigating pharmacokinetics, safety and efficacy in patients less than 12 years of age with severe hemophilia A that have been previously treated with Factor VIII products ( including blood products).

NCT ID: NCT00910910 Completed - Clinical trials for B-Cell Chronic Lymphocytic Leukemia

Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)

ORIGIN
Start date: October 13, 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the safety and efficacy of lenalidomide as a first line therapy in treating patients with B-cell Chronic Lymphocytic Leukemia. This study will compare the effects (good and bad) of lenalidomide with chlorambucil.

NCT ID: NCT00910247 Completed - Epilepsy Clinical Trials

Eslicarbazepine Acetate Monotherapy Long Term Study

Start date: August 2009
Phase: Phase 3
Study type: Interventional

This is a long term, open-label, safety extension study in subjects with partial onset seizures.

NCT ID: NCT00908232 Completed - Multiple Myeloma Clinical Trials

Treatment With Velcade (Bortezomib) Plus Dexamethasone (VD) or VD Plus Cyclophosphamide or VD Plus Lenalidomide in Patients With Multiple Myeloma Stabilized After 4 Cycles of VD

SEQUENTIAL
Start date: May 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test the effectiveness and safety of adding cyclophosphamide or lenalidomide to the VD combination in the treatment of patients with multiple myeloma that have achieved a stable response after 4 initial cycles of treatment with VD. Multiple myeloma is the second most common cancer of the blood. Bortezomib disrupts the life cycle of the cell, affecting numerous biologic pathways, including those related to growth and survival of cancer cells.

NCT ID: NCT00906399 Completed - Clinical trials for Relapsing Multiple Sclerosis

Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis

ADVANCE
Start date: June 2009
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to determine the efficacy of peginterferon beta-1a in reducing the annualized relapse rate (ARR) in participants with relapsing multiple sclerosis (RMS) at 1 year. The secondary objectives of this study are to determine whether peginterferon beta-1a, at 1 year when compared with placebo, is effective in reducing the total number of new or newly enlarging T2 hyperintense lesions on brain magnetic resonance imaging (MRI) scans, reducing the proportion of participants who relapse, and slowing the progression of disability.

NCT ID: NCT00905307 Completed - Schizophrenia Clinical Trials

Study to Evaluate the Efficacy, Safety, and Tolerability of Oral OPC-34712 and Aripiprazole for Treatment of Acute Schizophrenia

STEP 203
Start date: July 2009
Phase: Phase 2
Study type: Interventional

This will be a multicenter, randomized, double-blind, placebo-controlled study designed to assess the tolerability, safety, and efficacy of OPC-34712 (0.25 to 6.0 mg) for the treatment of adult subjects hospitalized with an acute relapse of schizophrenia. Aripiprazole (10 to 20 mg) is included as a positive control to confirm the assay sensitivity of the study. A total of approximately 563 subjects will be screened at an estimated 75 sites worldwide in order to obtain approximately 450 randomized subjects.

NCT ID: NCT00903383 Completed - Clinical trials for Rheumatoid Arthritis

Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate

Start date: July 2009
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the safety, tolerability, and effectiveness of LX3305 versus a placebo control in subjects with active rheumatoid arthritis on stable methotrexate therapy.

NCT ID: NCT00891202 Active, not recruiting - Clinical trials for Gaucher Disease, Type 1

A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease (ENGAGE)

Start date: November 2009
Phase: Phase 3
Study type: Interventional

This Phase 3 study is designed to confirm the efficacy and safety of eliglustat tartrate (Genz-112638) in participants with Gaucher disease Type 1.

NCT ID: NCT00883402 Recruiting - Carotid Stenosis Clinical Trials

Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients

ACST-2
Start date: January 2008
Phase: N/A
Study type: Interventional

The trial randomise patients with asymptomatic carotid artery narrowing in whom prompt physical intervention is thought to be needed, but there there is still substantial uncertainty shared by patient and doctor about whether surgery or stenting is the more appropriate choice. The study is looking at immediate risks (within one month)and at long term benefits

NCT ID: NCT00882999 Completed - Clinical trials for Relapsing-Remitting Multiple Sclerosis

A Study of Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)

Start date: April 2009
Phase: Phase 2
Study type: Interventional

To look at the ability of LY2127399 to reduce magnetic resonance imaging (MRI) lesions at 12, 16, 20, and 24 weeks compared to placebo.