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NCT ID: NCT05694858 Not yet recruiting - Cataract Clinical Trials

Transdermal Microneedle Lignocaine Delivery Versus EMLA Patch for Topical Analgesia Before Venepuncture Procedure To Adults in Clinical Setting

Start date: May 2, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Microneedle (MN) is a mimic of a hypodermic needle, composed of hundreds of micron-sized, out-of-plane protrusions, typically arranged in arrays on a patch that can be applied onto the skin. MN can be fabricated from a variety of materials, preferably biocompatible polymers. Maltose, a natural carbohydrate, is a safe and biocompatible product that can be fabricated into MNs that are biodegradable and soluble within several minutes. Besides, local anaesthetic agents such as lignocaine can be impregnated within the MN matrix, facilitating its transdermal delivery more efficiently which results in enhanced efficacy. So far, maltose MN efficacy in enhancing the transdermal drug delivery (TDD) of lignocaine and thus reducing the pain experienced by healthy patients requiring intravenous cannulation prior to routine eye surgeries (phacoemulsification, trabeculectomy etc) has not been extensively studied. Hence, the objectives of this research are: 1) To evaluate the safety profile of lignocaine-embedded microneedle patch as a means of pain reduction in adult patients requiring routine vein-puncturing procedures; 2) To assess the pharmacokinetic (PK) parameters of lignocaine in the systemic circulation when the transdermal lignocaine delivery is enhanced through microneedle usage; 3) To compare the efficacy of lignocaine-embedded microneedle patch with standard 5% Eutectic Mixture of Local Anesthetics (EMLA) dermal patch for pain reduction during venepuncture procedure based on mean changes in VAS scores and skin algesimeter index (pharmacodynamic (PD) study).

NCT ID: NCT05694442 Active, not recruiting - Healthy Clinical Trials

The Effect of Lipmatte K

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the safety and the effectiveness of Lipmatte K on lip hydration and brightening. The study duration is 4 weeks and the lip assessment will be carried out at baseline, week 2 and week 4.The main questions this study aims to answer are: 1. The hydration effect of the product on lip. 2. The brightening effect of the product on lip. 3. To observe any adverse effect occurrence with the usage of the product.

NCT ID: NCT05694429 Active, not recruiting - Healthy Clinical Trials

The Effect of the Combination of Cleanser and Moisturizer Product K

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the effectiveness of product K cleanser and moisturizer when use in combination for skin rejuvenation. The study duration is 8 weeks and the skin assessment will be carried out at baseline, week 2, week 4 and week 8.The main questions this study aims to answer are: 1. The effect of cleanser and moisturizer K when use in combination on skin hydration. 2. The effect of cleanser and moisturizer K when use in combination on skin elasticity. 3. To observe any adverse effect occurrence with the usage of the products.

NCT ID: NCT05694182 Recruiting - Healthy Clinical Trials

The Safety and Efficacy of an Oral Superfruits Supplement

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the safety and effectiveness of an oral superfruits supplement for skin brightening and wrinkle reduction. Superfruits are reported to have high bioactive compounds with beneficial effects on human health. The study duration is 12 weeks and the skin assessment will be carried out at baseline, week 2, week 6 and week 12. The participants will consume the supplement for 6 weeks and at week 12, final skin assessment will be conducted. The main questions this study aims to answer are: 1. The skin brightening effect of the oral superfruits supplement. 2. The effect of the oral superfruits supplement on wrinkle reduction. 3. To observe any adverse effect occurrence with the consumption of the oral superfruits supplement.

NCT ID: NCT05694143 Recruiting - Adolescents Obesity Clinical Trials

the Effectiveness of Health Literacy Intervention Among Middle Eastern Adolescents in Malaysia

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

In Malaysia, Middle Eastern adolescents are going through changes in living status, yet few studies show that overweight and obesity are prevalent among Arabic secondary school students. There have not been any intervention studies among Middle Eastern adolescents in Malaysia. The current study aims to determine the effects of an intervention program on physical activity and healthy diet behavior among Middle Eastern adolescent students in Arabic schools in Malaysia

NCT ID: NCT05693948 Recruiting - Healthy Clinical Trials

The Efficacy of Topical Serum X

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the effectiveness of topical serum X containing arbutin and glutathione for skin brightening. The study duration is 12 weeks and the skin assessment will be carried out at baseline, week 4, 8 and week 12.The main questions this study aims to answer are: 1. The skin brightening effect of the product on facial skin. 2. To observe any adverse effect occurrence with the usage of the product.

NCT ID: NCT05691413 Recruiting - Healthy Clinical Trials

Safety and Efficacy of Facial Cleanser

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the safety and effectiveness of facial cleanser X containing combination of olive oil, virgin coconut oil, butylene glycol and hyaluronic acid on skin hydration and skin elasticity. The study duration is 5 weeks and the skin assessment will be carried out at baseline, week 3 and week 5.The main questions this study aims to answer are: 1. The effect of product on skin hydration. 2. The effect of product on skin elasticity. 3. To observe any adverse effect occurrence with the usage of the product.

NCT ID: NCT05689957 Completed - Clinical trials for Neuromuscular Blockade

Moderate vs Deep Neuromuscular Block in Lower Pressure Pneumoperitoneum

Start date: December 13, 2020
Phase: N/A
Study type: Interventional

The investigators hypothesized that deep neuromuscular block compare to moderate neuromuscular block would reduce the rate of increasing intraabdominal pressure and operation can be completely done in lower pressure pneumoperitoneum and would improve laparoscopic space by measuring distance from the sacral promontory to the inserted trocar in patients undergoing laparoscopic gynaecological surgery.

NCT ID: NCT05688748 Not yet recruiting - Dengue Clinical Trials

Effectiveness Evaluation of a Dengue Self-monitoring System

DeSMoS
Start date: January 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare the effectiveness of a dengue self-monitoring system with standard care in reducing treatment delay among dengue patients receiving outpatient care. The main question it aims to answer are: • Is a dengue self-monitoring system effective in reducing treatment delay in dengue patients? Participants will use the dengue monitoring system in addition to the standard care they are receiving for outpatient follow up for dengue. Researchers will compare them with dengue patients receiving the usual standard care to see if the dengue monitoring system reduces delay in treatment seeking in patients.

NCT ID: NCT05687591 Recruiting - Atrial Fibrillation Clinical Trials

Left Atrial Appendage Occlusion With The Amplatzer Amulet Device: The Southeast Asia Observational Study

Start date: October 1, 2022
Phase:
Study type: Observational

This is a prospective and retrospective, multicenter observational study where the study is being performed to explore on the short-term and long-term safety and efficacy of LAA occlusion with Amplatzer Amulet Device in Southeast Asia population on a real-world basis.