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NCT ID: NCT06387212 Recruiting - Skin Inflammation Clinical Trials

35 kDa Hyaluronan Fragment (HA35) Reduces Chronic Inflammation of Skin

Start date: April 15, 2024
Phase: N/A
Study type: Interventional

To explore the clinical effect and safety of 35 kDa hyaluronic acid fragment ( HA35 ) combined with negative pressure microneedle technology in improving skin problems.

NCT ID: NCT06137950 Recruiting - HPV Infection Clinical Trials

Interferon Alpha Therapy for Cervical CINI and HPV Infection

Start date: November 7, 2023
Phase: Phase 1
Study type: Interventional

Mongolia is a traditionally nomadic and population is scarce in rural areas. Thus, the medical care service is not sufficient. In 2000, Mongolian government has developed and implemented the millennium project in cooperation with WHO. During the years pap smear analysis of implemented in all rural areas and clinicians, lab technicians have been taught for the cervical cancer screening. However, the project has finished in 2015 and the rural and district hospitals has lost the trained professionals. Still the cervical cancer is in second place after liver cancer in women. The purpose of the study is to identify the type of HPV genotype and to treat the HPV infection by local interferon α2b. Materials and methods: HPV positive patients will be enrolled to the study. HPV genotype will be determined by the PCR in laboratory. Pap smear will be taken and staged by the CIN. Pathological tissue will be taken under colposcopy with acetic acid test. Follow up visit will be done on 10th, 30th days of the treatment. At the end of 90th days of treatment, pap and histology test will be repeated and CIN regression or viral eradication will be evaluated.

NCT ID: NCT04305704 Recruiting - Vascular Diseases Clinical Trials

Coated Mongolian Aneurysm Treatment Study 2

COMATS 2
Start date: February 8, 2020
Phase:
Study type: Observational

The purpose of this study is to assess safety and effectiveness of the p64 MW HPC or p48 MW HPC Flow Modulation Device under prasugrel.

NCT ID: NCT04305626 Recruiting - Vascular Diseases Clinical Trials

Coated Mongolian Aneurysm Treatment Study 1

COMATS 1
Start date: June 22, 2019
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to assess safety and effectiveness of the p64 MW HPC or p48 MW HPC Flow Modulation Device under Dual Antiplatelet Medication.

NCT ID: NCT04126135 Recruiting - Nicotine Addiction Clinical Trials

Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy

Start date: January 27, 2022
Phase: Phase 3
Study type: Interventional

A pragmatic, single blinded, randomized, controlled non-inferiority trial of Cytisine versus Nicotine Replacement Therapy for continuous abstinence is conducted in the government run primary health hospitals in Mongolia.

NCT ID: NCT03916757 Recruiting - Clinical trials for Glioblastoma Multiforme

V-Boost Immunotherapy in Glioblastoma Multiforme Brain Cancer

GBM
Start date: April 16, 2019
Phase: Phase 2
Study type: Interventional

The Phase II study to determine the safety and efficacy of V-Boost in treating a type of brain cancer called Glioblastoma Multiforme (GBM). V-Boost is an immunotherapy in which the patient's immune system will be modulated to eliminate tumor cells. V-Boost is made as an oral tablet which contains specially formulated hydrolyzed GBM antigens along with alloantigens. Patients are either newly diagnosed or with recurrent form of GBM who may have been subjected to surgery and/or chemo- or radiation therapy that ended up unsuccessful. The goal is to eradicate GBM tumor cells through daily oral administration of one pill of V-Boost immunotherapeutic vaccine, which so far has not shown any adverse reaction.

NCT ID: NCT03835806 Recruiting - Blister of Foot Clinical Trials

Blister Eradication Looking at Impact of Experimental Versus Established Regimens

BELIEVER
Start date: April 27, 2019
Phase: N/A
Study type: Interventional

The specific aim of this study is to evaluate whether RockTape has similar efficacy to Elastikon in the treatment of foot blisters in ultramarathon runners. Elastikon with paper tape and spray adhesive is a well-accepted means of blister treatment and has been used by medical staff at over 50 multi-stage ultramarathons around the world. RockTape is another commercially available product that has also been used by runners successfully to treat foot blisters. RockTape's adhesive qualities have a potential advantage over Elastikon, in that it does not require an additional adhesive substituting a level of complexity, weight, and cost for foot care. There have been no studies examining the efficacy of either agent for blister treatment. This randomized controlled trial will compare the traditional method of treating blisters with a multi-step approach of percutaneous drainage, paper tape, spray adhesive and then Elastikon to percutaneous drainage, paper tape and RockTape.

NCT ID: NCT03572361 Recruiting - Breast Cancer Clinical Trials

Open Label Immunotherapy Trial for Breast Cancer

V3-MOMMO
Start date: July 1, 2018
Phase: Phase 2
Study type: Interventional

This Phase II will evaluate a new type of breast cancer immunotherapy based on a fundamentally new approach that has been successfully tested in a published clinical study of liver cancer. Investigators will test new tableted preparation, V3-MOMMO, obtained from hydrolyzed, inactivated blood and tumors of patients with breast cancer. Study will last 3 months, 20 patients will be recruited, given one pill per day for three months. The primary clinical endpoint is effect on tumor size and burden after 3 months. Secondary endpoint will be effect on levels of tumor markers on monthly basis compared to baseline.

NCT ID: NCT03556566 Recruiting - Ovarian Cancer Clinical Trials

Open Label Immunotherapy Trial for Ovarian Cancer

V3-OVA
Start date: July 1, 2018
Phase: Phase 2
Study type: Interventional

This Phase II will evaluate a new type of ovarian cancer immunotherapy based on a fundamentally new approach that has been successfully tested in a published clinical study of liver cancer. We will test new tableted preparation, V3-OVA, obtained from hydrolyzed, inactivated blood and tumors of patients with cancer of ovaries. Study will last 3 months, 20 patients will be recruited, given one pill per day for three months. The primary clinical endpoint is effect on tumor size and burden after 3 months. Secondary endpoint will be effect on levels of tumor markers on monthly basis compared to baseline.

NCT ID: NCT03550755 Recruiting - Cervical Cancer Clinical Trials

Immunotherapy of Cervical Cancer With V3-Cervix

V3-Cervix
Start date: July 1, 2018
Phase: Phase 2
Study type: Interventional

The goal of this trial is to evaluate the efficacy of immunotherapy for cervical cancer based on a fundamentally new approach. We will test new tableted preparation, V3-Cervix, obtained from hydrolyzed, inactivated blood and tumors of patients with cervical cancer. When administered orally, it should cause a specific anti-tumor immune response and an anti-inflammatory effect. Trial is planned to last 3 months, recruit 20 volunteers, administer daily pill of vaccine and evaluate effect on tumor size and tumor markers.