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NCT ID: NCT02770131 Completed - Clinical trials for Hypercholesterolaemia

Chart Review of Repatha® in Subjects With Hyperlipidaemia

HEYMANS
Start date: May 4, 2016
Phase:
Study type: Observational

Review of clinical characteristics of patients who are prescribed Repatha® and how their treatment is managed.

NCT ID: NCT02763579 Completed - Clinical trials for Small Cell Lung Carcinoma

A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage (ES) Small Cell Lung Cancer (SCLC)

IMpower133
Start date: June 7, 2016
Phase: Phase 3
Study type: Interventional

This randomized, Phase I/III, multicenter, double-blinded, placebo-controlled study was designed to evaluate the safety and efficacy of atezolizumab (anti-programmed death-ligand 1 [PD-L1] antibody) in combination with carboplatin plus (+) etoposide compared with treatment with placebo + carboplatin + etoposide in chemotherapy-naive participants with ES-SCLC. Participants will be randomized in a 1:1 ratio to receive either atezolizumab + carboplatin + etoposide or placebo + carboplatin + etoposide on 21-day cycles for four cycles in the induction phase followed by maintenance with atezolizumab or placebo until progressive disease (PD) as assessed by the investigator using Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1). Treatment can be continued until persistent radiographic PD or symptomatic deterioration.

NCT ID: NCT02761187 Completed - Multiple Myeloma Clinical Trials

An Observational Study of Presentation, Treatment Patterns, and Outcomes in Multiple Myeloma Participants

Start date: July 1, 2016
Phase:
Study type: Observational

The purpose of this study is to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapeutic regimen chosen, and clinical outcomes in participants with newly diagnosed [ND] multiple myeloma (MM) and participants with relapsed/refractory [R/R] MM.

NCT ID: NCT02760498 Completed - Clinical trials for Advanced Cutaneous Squamous Cell Carcinoma

Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell Carcinoma

Start date: April 7, 2016
Phase: Phase 2
Study type: Interventional

Groups 1 to 4 To estimate the clinical benefit of cemiplimab monotherapy for patients with: metastatic (nodal or distant) cutaneous squamous cell carcinoma (CSCC), or unresectable locally advanced CSCC Group 6 To provide additional efficacy and safety data for cemiplimab monotherapy in patients with advanced CSCC (metastatic [nodal or distant] or locally advanced treated with cemiplimab

NCT ID: NCT02756611 Completed - Clinical trials for Chronic Lymphocytic Leukemia

A Study to Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)

VENICE I
Start date: June 22, 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of venetoclax monotherapy in participants with relapsed/refractory CLL with or without the 17p deletion or TP53 mutation, including those who have received prior treatment with a B-cell receptor inhibitor.

NCT ID: NCT02753946 Completed - Clinical trials for Acute Pyelonephritis

Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections

ZEUS
Start date: April 2016
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of the study is to demonstrate the safety and efficacy of ZTI-01 (IV fosfomycin) as non-inferior to piperacillin/tazobactam in overall success (clinical cure and microbiologic eradication) for the treatment of hospitalized patients with complicated urinary tract infections (cUTI) or acute pyelonephritis (AP).

NCT ID: NCT02752776 Completed - Plaque Psoriasis Clinical Trials

A Study to Evaluate Clear Skin Effect on Quality of Life in Patients With Plaque Psoriasis.

PROSE
Start date: March 17, 2016
Phase: Phase 4
Study type: Interventional

Study of effects of secukinumab 300 mg s.c. on quality of life (QoL) in psoriasis in patients with or without prior exposure to systemic therapy.

NCT ID: NCT02747043 Completed - Clinical trials for Lymphoma, Non-Hodgkin

Study to Assess if ABP798 is Safe & Effective in Treating Non Hodgkin Lymphoma Compared to Rituximab

JASMINE
Start date: May 25, 2016
Phase: Phase 3
Study type: Interventional

This was a randomized, double-blind, active-controlled, multiple-dose, clinical similarity study to evaluate the efficacy, pharmacokinetics, pharmacodynamics, safety, tolerability and immunogenicity of ABP 798 compared with rituximab in subjects with grade 1, 2, or 3a follicular B-cell NHL and low tumor burden. Subjects were randomized in a 1:1 ratio to receive a 375 mg/m^2 intravenous infusion of either ABP 798 or rituximab once weekly for 4 weeks followed by dosing at weeks 12 and 20.

NCT ID: NCT02746471 Completed - Clinical trials for Arrhythmias, Cardiac

Reveal LINQ Registry

Start date: April 2014
Phase:
Study type: Observational

The Reveal LINQ Registry will generate reliable long-term "real world" data of product performance, economic valuation, site-of-service procedural information.

NCT ID: NCT02746159 Completed - Clinical trials for Arteriovenous Fistula

Lutonix® Global AV Registry Investigating Lutonix Drug Coated Balloon for Treatment of Native and Synthetic AV Fistulae

AVR
Start date: June 7, 2016
Phase:
Study type: Observational [Patient Registry]

The purpose of this Registry is to enroll patients presenting with clinical and hemodynamic abnormalities in native or synthetic (grafts) arteriovenous (AV) fistulae located in the arm. Subjects will be treated with the Lutonix DCB carrying the CE Mark per current IFU and followed clinically for a minimum of 12 months.