Clinical Trials Logo

Filter by:
NCT ID: NCT01421368 Completed - HIV Prevention Clinical Trials

Contraception and Menstrual Cycle Effect on Pharmacokinetics, Pharmacodynamics and Safety in Tenofovir Vaginal Gel Use

Start date: March 2012
Phase: Phase 1
Study type: Interventional

The purpose of the study is to examine the effects of two contraceptive methods and the menstrual cycle on the pharmacokinetics, pharmacodynamics of tenofovir 1% gel and the effect of the contraceptive methods on markers of mucosal safety.

NCT ID: NCT01369303 Completed - Prevention Clinical Trials

Pharmacokinetic and Pharmacodynamic Study of Tenofovir 1% Gel

Start date: January 2012
Phase: Phase 1
Study type: Interventional

The purpose of the study is to obtain data on the pharmacokinetics (PK) and pharmacodynamics (PD) and immune system effect of the BAT24 dosing regimen versus daily and pericoital dosing regimens with vaginal use of tenofovir 1% gel after a single sex act and after multiple sex acts.

NCT ID: NCT01367314 Completed - Impetigo Clinical Trials

Safety and Efficacy of Topical NVC-422 Gel in Impetigo

Start date: August 2009
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind study comparing 0.1% NVC-422, 0.5% NVC-422 and 1.5% NVC-422 topical gel in children with impetigo.

NCT ID: NCT01363011 Completed - HIV Infections Clinical Trials

Cobicistat-containing Highly Active Antiretroviral Regimens in HIV-1 Infected Patients With Mild to Moderate Renal Impairment

Start date: May 2011
Phase: Phase 3
Study type: Interventional

This study is to characterize the effect of cobicistat-based regimens on parameters of renal function in subjects with HIV infection and who have mild to moderate renal impairment, and to assess the safety and tolerability of the regimens in order to generate appropriate dosing recommendations.

NCT ID: NCT01318941 Completed - Clinical trials for Diabetic Macular Edema

Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting

LUMINOUS
Start date: March 2011
Phase: N/A
Study type: Observational

This study will describe the long-term safety and effectiveness, treatment patterns,and patient reported quality of life associated with ranibizumab treatment in routine clinical practice for all approved indication included in the local product label.

NCT ID: NCT01286948 Completed - Clinical trials for Female Contraception

Prevention of Ovulation Achieved by Single Intra-vaginal Administration of Levogel as Compared to Oral LNG

Start date: January 2011
Phase: Phase 1
Study type: Interventional

It has been proposed that levonorgestrel (LNG) in a vaginal gel could be used as an 'on demand' contraceptive when used before coitus. Levonorgestrel was selected as it is a component of many approved oral contraceptive pills and also it is the active agent in Plan B, an FDA-approved regimen for emergency contraception (EC). In previous studies it was demonstrated that an LNG vaginal gel was absorbed and was effective in preventing follicular rupture. The overall proportion of cycles with lack of follicular rupture within 5 days of LNG administration or with ovulatory dysfunction (follicle rupture preceded by an inadequate LH surge) was 96% for LNG gel and 39% in the inert gel cycles (control group).

NCT ID: NCT01283555 Completed - Clinical trials for Microbicide Applicator

Comparative Safety Study of Two Vaginal Applicators With Tenofovir

Start date: January 2011
Phase: N/A
Study type: Interventional

The primary objective of this study is to compare the effect of two vaginal applicators, delivering the candidate microbicide Tenofovir, on symptoms and signs of irritation of the external genitalia, cervix and vagina as seen on colposcopy after seven days of twice daily use. The secondary objectives are to: 1. Evaluate and compare the dosing accuracy and precision of the user-filled applicator and pre-filled applicator with the candidate microbicide, Tenofovir. 2. Compare the acceptability of the user-filled applicator with the pre-filled applicator.

NCT ID: NCT01248884 Completed - Hepatitis B Clinical Trials

Safety and Immunogenicity of New Formulations of GlaxoSmithKline Biologicals' DTPa-HBV-IPV/Hib Vaccine (GSK217744)

Start date: December 9, 2010
Phase: Phase 2
Study type: Interventional

This study is designed to evaluate the safety and immunogenicity of new formulations of GSK Biologicals' DTPa-HBV-IPV/Hib vaccine (GSK217744) when administered as a primary vaccination course to healthy infants at 2, 3 and 4 months of age.

NCT ID: NCT01228916 Completed - Clinical trials for Tobacco Use Cessation

Community-Partnered Dominican Republic Tobacco Control

Start date: June 2010
Phase: N/A
Study type: Interventional

Tobacco use and tobacco-caused illnesses and death are increasing in developing countries globally, so it is critical to study these countries in order to effectively address the tobacco epidemic. The proposed project will test the effectiveness of community-based interventions for secondhand smoke and quitting smoking in eight underserved communities in the Dominican Republic. The project will also partner with communities and national and international groups to determine whether the methods and interventions from this study in the Dominican Republic can also be used to help other countries in the region and underserved groups in the United States.

NCT ID: NCT01218308 Completed - Influenza Clinical Trials

A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children

Start date: December 9, 2010
Phase: Phase 3
Study type: Interventional

This study is designed to test the efficacy of an investigational influenza vaccine, in children compared to Havrix®, a licensed Hepatitis A virus vaccine. This study will also evaluate the immunogenicity and safety of the investigational vaccine.