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NCT ID: NCT02600390 Completed - Leg Ulcer Clinical Trials

SANGUINATE™ in Sickle Cell Disease Associated Leg Ulcer

LU
Start date: March 2016
Phase: Phase 2
Study type: Interventional

SANGUINATE™ Sickle Cell Disease associated Leg Ulcers.

NCT ID: NCT02594371 Completed - Clinical trials for Metastatic Breast Cancer

Ph3 Study To Determine Safety,Tolerability&Tumor Response Of Oraxol Compared To Taxol In Metastatic Breast Cancer

Start date: December 2, 2015
Phase: Phase 3
Study type: Interventional

To determine the safety and tolerability of Oraxol as compared to IV paclitaxel in metastatic breast cancer

NCT ID: NCT02562482 Completed - Clinical trials for Chikungunya Virus Infection

Trial for Safety and Immunogenicity of a Chikungunya Vaccine, VRC-CHKVLP059-00-VP, in Healthy Adults

Start date: November 18, 2015
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety and immunogenicity of a 2-injection vaccine Chikungunya virus (CHIKV) virus-like particle vaccine (CHIKV VLP) in healthy adults.

NCT ID: NCT02466867 Completed - Tinea Corporis Clinical Trials

An Open Label Pharmacokinetic Study of Naftin for Tinea Corporis

Start date: January 2014
Phase: Phase 4
Study type: Interventional

This is an open label, multi-center, multi-application pharmacokinetic study in pediatric subjects with tinea corporis.

NCT ID: NCT02456584 Completed - Contraception Clinical Trials

Pharmacodynamics and Pharmacokinetics Study of Existing DMPA Contraceptive Methods

Start date: September 2015
Phase: Phase 1
Study type: Interventional

This is a randomized, multi-center, parallel-group Phase I study to evaluate the pharmacodynamics (PD) of Medroxyprogesterone Acetate (MPA) after a single subcutaneous (SC) injection of 150 mg/mL or 300 mg/2 mL Depo-Provera CI in the abdomen of women of reproductive age with a confirmed ovulatory baseline cycle.

NCT ID: NCT02455622 Active, not recruiting - Hunter Syndrome Clinical Trials

Long-term Evaluation on Height and Weight in Patients With MPS II Who Started Treatment at < 6 Years of Age

Start date: October 28, 2015
Phase: Phase 4
Study type: Interventional

This long-term study will provide Elaprase treatment to children enrolled in this study and will utilize data from both enrolled patients and Hunter Outcome Survey (HOS) patient registry data to conduct the primary growth analysis to assess changes in height and weight in patients with Mucopolysaccharidosis II (Hunter syndrome) MPS II.

NCT ID: NCT02451826 Active, not recruiting - Clinical trials for Ovulation Inhibition

A Study to Evaluate the Effect of a Contraceptive Vaginal Ring Delivering Ulipristal Acetate Combined With a Single or Repeated Levonorgestrel on Inhibition of Ovulation, Endometrial Changes and Bleeding Patterns in Normal Cycling Women

Start date: May 2015
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine the effect of a contraceptive vaginal ring on inhibition of ovulation, endometrial changes and bleeding patterns in normal cycling women.

NCT ID: NCT02435615 Terminated - Dengue Clinical Trials

Diagnosing Dengue: Evaluating the Utility of Oral Fluid for Dengue Diagnosis

Start date: January 2016
Phase: N/A
Study type: Interventional

Dengue is the most common viral illness spread by mosquitos. It is important to diagnose dengue to prompt adequate therapy and initiate local mosquito control. Easy to use point of care tests are needed to improve dengue diagnosis. Oral fluid collection may be a simple, non-invasive way to diagnose dengue in the community. However, it is currently unknown if oral fluid is an accurate way to diagnose dengue and if the use of a specialized oral fluid collector could help to improve dengue diagnosis. In this study, the investigators will analyze the oral fluid of suspected dengue patients compared to serum samples for dengue diagnosis. From this information the investigators will be able to determine if oral fluid is a convenient way to diagnose dengue and if the oral fluid collector aids in improving diagnosis.

NCT ID: NCT02434822 Completed - Cholera Clinical Trials

A Study of Two Doses of Oral Cholera Vaccine (Shanchol™) in Subjects Aged 1 Year and Older in Dominican Republic

Start date: April 2015
Phase: Phase 3
Study type: Interventional

The aim of the study is to generate safety and immunogenicity data with Shanchol in The Philippines Objectives: - To describe the safety after each dose of Shanchol vaccine. - To describe the immunogenicity after each dose of Shanchol vaccine.

NCT ID: NCT02347423 Completed - Poliomyelitis Clinical Trials

3 Adjuvated Reduced Dose IPV-Al SSI and Non-adjuvated Full Dose IPV SSI Given as Primary Vaccinations to Infants

Start date: February 2015
Phase: Phase 2
Study type: Interventional

The background of the present clinical trial is the overall aim of the World Health Organization (WHO) to obtain eradication of polio in the world. As part of this overall plan, inactivated polio vaccine (IPV) against poliovirus types 1, 2 and 3, at an affordable price, needs to be available in low resource third world countries. The intention of the present phase II clinical trial is to determine if reduced dose(s) of IPV-Al SSI are safe in the target population and do not decrease the immunogenicity clinically significantly compared to full dose IPV Vaccine SSI. The infants will receive three doses of one of the trial vaccines according to the WHO Expanded Program on Immunization (EPI) schedule of 6, 10 and 14 weeks of age. A total of 824 healthy infants will be included in the trial.