Neuropathic Pain Clinical Trial
Official title:
Analysis of Cortical Excitability in Neuropathic Pain: an Electrophysiology Study.
The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.
There are several brain areas responsible for neuropathic pain reported in functional image
studies, including primary sensory cortex, insula, and anterior cingulate gyrus. However, it
is few informations about the functional status of these areas. Besides, the reason of the
individual variability about the developement of neuropathic pain remains unknown. It is
lack of satisfactory explanation about why some people developed neuropathic pain in certain
diseased situation (for example, type 2 diabetes), while others do not.
We hypothesis that patients with neuropathic pain has abnormal cortical excitability and
plasticity in certain brain area. Therefore developed neuropathic pain certain diseased
condition while others not. Therefore, we will use multimodal electrophysiology tools,such
as transcranial magnetic stimulation, peripheral nerve stimulation, and contact heat evoke
potential to monitor the cortical excitability and plasticity non-invasively.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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