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Identification of Biomarkers in Subjects With Coronary Syndrome (PLAQUE Study) — PLAQUE  

Coronary Syndrome Clinical Trial

Official title:
Identification of Innovative Circulating and Cellular Biomarkers in Subjects With Acute and Chronic Coronary Syndrome (PLAQUE Study)

Clinical Trial Summary

The study will to test the levels of innovative biomarkers, such as miRNAs, in the blood of subjects underwent to angioplasty procedure according to standard clinical practice.

Clinical Trial Description

Twenty patients with acute coronary syndrome from non-ST-segment elevation myocardial infarction or with chronic coronary syndrome with clinical indication and favorable anatomy for coronary angioplasty will be enrolled. The angioplasty procedure will be performed according to standard clinical practice. Before and after angioplasty, blood samples will be taken upstream and downstream of the coronary lesion, arterial sampling will be performed at the level of the aortic root, and peripheral venous blood will be collected. MicroRNA expression will be analyzed in serum by next-generation sequencing (miRNome). Quantitative analysis of pro- and anti-inflammatory molecules such as IL-6 and the soluble form of IL-33 receptor (sST2) will be performed on various blood samples. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06103357
Study type Observational
Source Istituto Nazionale di Ricovero e Cura per Anziani
Contact Anna Rita Bonfigli, PhD
Phone 0718003719
Email a.bonfigli@inrca.it
Status Recruiting
Phase
Start date March 6, 2023
Completion date April 30, 2024
View Details
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