Coronary Artery Bypass Clinical Trial
Official title:
The Effects of Atorvastatin on the Occurrence of Postoperative Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery
The purpose of this study is to determine whether pretreatment with atorvastatin protects against atrial fibrillation following off-pump coronary artery bypass graft surgery.
Atrial fibrillation after cardiac surgery is the most common arrhythmic complication that
may increase incidence of congestive heart failure, renal insufficiency, and stroke, which
increase the length of hospital stay, the rates of re-hospitalization, and cost of care. Its
pathogenesis is multifactorial, and its prevention and management remain suboptimal.
Recently, observational evidence has suggested that patients who have undergone previous
statin therapy have a lower incidence of postoperative atrial fibrillation.
The purpose of this study is to determine whether pretreatment with atorvastatin protects
against atrial fibrillation following off-pump coronary artery bypass graft surgery.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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