Corneal Opacity Clinical Trial
Official title:
Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
Optical Coherence Tomography (OCT) machines are non-contact instruments that can measure the depth of scars and other causes of cloudiness in the front of the cornea. The purpose of this study is to determine whether OCT-guided settings for the lasers used for removal of corneal scars and other partial-thickness corneal defects result in improved vision in patients receiving these procedures.
The long-term goal of this project is to utilize newly available very high-speed OCT technology to guide surgical treatments of corneas with superficial opacities and irregularities. OCT is well known for its exquisite resolution, but until recently it has not had sufficient speed to capture the shape of the cornea because of eye motion during OCT scanning. The development of Fourier-domain OCT (FD-OCT) technology has made the requisite speed possible. Eyes with superficial opacities (corneal scars and stromal dystrophies) can be treated by phototherapeutic keratectomy (PTK). Currently, many surgeons rely on subjective slit-lamp impression of opacity depth to guide PTK and repeat slit-lamp examinations during surgery to determine if the opacity has been sufficiently reduced. Unpredictable hyperopic shifts can occur after PTK. The aim of this project is to develop methods for imaging the cornea with an FD-OCT system that will precisely measure corneal shape and use this information to guide surgery. Patients with irregularly shaped corneas could have their vision restored by reshaping the corneas with a procedure that combines the precision of OCT and lasers. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03123614 -
Loteprednol vs. Prednisolone and Fluorometholone
|
Phase 4 | |
Withdrawn |
NCT03421548 -
Implantable Intraocular Pressure Sensor for Glaucoma Monitoring in Patients With Boston Keratoprosthesis Type 1
|
N/A | |
Not yet recruiting |
NCT05345652 -
Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography
|
||
Recruiting |
NCT03504800 -
OCT in Diagnosis of Irregular Corneas
|
||
Recruiting |
NCT05694247 -
Study to Evaluate the Clinical Safety and Performance of the CorNeat KPro for Treatment of Corneal Blindness
|
N/A | |
Recruiting |
NCT04120389 -
Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery
|
N/A | |
Completed |
NCT04752969 -
The Effect of Thyroid Hormon Levels on the Corneal Measures
|
||
Completed |
NCT00439114 -
Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze
|
N/A | |
Not yet recruiting |
NCT06174376 -
Clinical Outcomes of the Gore Synthetic Cornea Device
|
N/A | |
Terminated |
NCT04485858 -
First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness
|
N/A | |
Terminated |
NCT01579643 -
OCT-guided LALAK in Children
|
N/A | |
Completed |
NCT02301598 -
Femtosecond Laser-assisted Anterior Lamellar Keratoplasty
|
N/A | |
Completed |
NCT02173847 -
Laser Assisted Procedures in Penetrating Keratoplasty
|
N/A | |
Completed |
NCT06000150 -
Characteristics of Trachomatous Corneal Opacity in Fayoum University Hospital
|
||
Recruiting |
NCT02826174 -
Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP
|
N/A | |
Active, not recruiting |
NCT02030990 -
The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements
|
Phase 2/Phase 3 | |
Terminated |
NCT01901614 -
OCT-guided LALAK for KCN
|
N/A | |
Active, not recruiting |
NCT00492245 -
Phototherapeutic Keratectomy (PTK) With Mitomycin in Adenoviral Opacities
|
N/A |