OCT-guided LALAK in Children

Status Terminated

Clinical Trial Summary

The primary goal of the trial is to determine if laser-assisted lamellar anterior keratoplasty (LALAK) will reduce the risks of post-operative complications such as adhesions, glaucoma and cataract that are associated with pediatric penetrating keratoplasty (PK).

Clinical Trial Description

There is a great need for lamellar keratectomy in the treatment of congenital opacities because the rejection rate in pediatric PK is 4-5 times higher than in adults. In addition, the intraocular inflammatory reaction in infants often leads to synechiae, glaucoma, and cataract. Because LALAK does not penetrate the eye and preserves the host endothelium, it could reduce the risk of these complications. Keratoplasty must be performed at this early age to prevent amblyopia.

In this study, OCT-guided LALAK will be performed in patients whose vision is limited by opacity in the anterior 2/3 of the cornea. The objective is to determine if LALAK will provide an equal or better visual outcome than traditional PK without the associated post-operative complications. ;

Study Design

Related Conditions & MeSH terms

Corneal Opacity

Clinical Trial Details

NCT number	NCT01579643
Study type	Interventional
Source	Oregon Health and Science University
Contact
Status	Terminated
Phase	N/A
Start date	January 2012
Completion date	August 31, 2016

View Details

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OCT-guided LALAK in Children — LALAK

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms