Clinical Trials Logo
  1. Home
  2. Cornea
  3. NCT04560790

Safety and Efficacy of CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy to Treat Refractory Viral Keratitis

Cornea Clinical Trial

Official title:
CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy Assisted Corneal Transplantation in the Treatment of Refractory Viral Keratitis

Clinical Trial Summary

The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of BD111 CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy administered via corneal injection in participants with refractory herpetic viral keratitis.

Clinical Trial Description

This is an open-label, single ascending dose study of BD111 in adult (ages 18 to 70) participants with refractory herpetic viral keratitis. Approximately 6 participants will be enrolled.BD111 is a novel gene editing product designed to clear Herpes simplex virus type I (HSV-1) that results in herpetic stromal keratitis in both acute and recurrent infection models which is the leading factor for infectious blindness. The follow-up period was 360 days, and the patients will be followed up 3±1 days, 7±2 days, 30±7 days, 90±14 days, 180±21 days, and 360+31 days after treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04560790
Study type Interventional
Source Shanghai BDgene Co., Ltd.
Contact
Status Completed
Phase N/A
Start date November 4, 2020
Completion date July 5, 2022
View Details
See also
  Status Clinical Trial Phase
Terminated NCT03674892 - Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain N/A
Recruiting NCT04439552 - fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Not yet recruiting NCT04122651 - Toric Intraocular Lenses for Cataract Patients in the NHS N/A
Recruiting NCT03299530 - Accuracy of Corneal Astigmatism in Different Region Modes
Recruiting NCT03010748 - Multi-center Clinical Trial on Corneal Morphology Analysis in Chinese Population
Completed NCT02293122 - To Investigate Agreement Between the EM-3000 and the Predicate Device Noncon Robo Pachy (F&A) (CellChek XL)
Active, not recruiting NCT06389916 - Euclid Phoenix Lens Design Trial N/A
Completed NCT06353776 - MicroPulse Transscleral Laser Therapy and Its Short-term Impact on Ocular Surface N/A
Completed NCT03906513 - Evaluation of the Efficacy of OMK2 in Recovering Corneal Neural Damage in Patients With Diabetes N/A
Not yet recruiting NCT06392607 - Euclid Phoenix Lens Design Trial 2 N/A
Recruiting NCT05232539 - Efficiency of Intraoperative Optical Coherence Tomography (iOCT) N/A
Completed NCT02781948 - Evaluation of the Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping With iVue SD-OCT N/A
Not yet recruiting NCT05345652 - Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography
Completed NCT04804592 - Investigation in Corneal Sensation and Contact Lens Wear N/A
Recruiting NCT04626583 - Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells Phase 1
Recruiting NCT04323358 - Agreement and Accuracy of Different Devices for Biometry Measurements in Patients With Cataract N/A
Completed NCT06277349 - Multifocal-toric IOL Compared to Multifocal IOL Combined With Limbal Relaxing Incisions for Correction of Moderate Astigmatism During Cataract Surgery N/A
Withdrawn NCT02395952 - Healing of Persistent Epithelial Defects N/A
Completed NCT03518775 - Repeatability and Reproducibility of the IOLMaster 700 Vers 1.70 and Agreement With IOLMaster 700 Vers. 1.50 and Pentacam
Terminated NCT04969406 - A Prospective Trial of the Intelon BOSS(TM) System N/A