Cornea Clinical Trial
Official title:
The Marker Expression of Corneal Surface From Penetrating Keratopathy After Collagenase A Assisted COMET Case Series
In order to examine the cells of the corneal epithelium in the patients who receive corneal transplantation after collagenase A assisted cultivated oral mucosa epithelium transplant (CA-COMET), we analyzed the specimens from penetrating keratoplasty with immunochemical staining.
Limbal insufficiency may cause persistent corneal erosion, turbidity, and even infection and
blindness, leading to major eye damage. In patients with limbal stem cell insufficiency, due
to the defect of the limbal stem cells, the new epidermal cells cannot be produced, and
without the limbus as a barrier, the cells near the conjunctiva will move toward the center
of the cornea, result in replacing the corneal cells and causing corneal conjunctivalization.
In recent years, many surgical methods for treating corneal stem cell defects include
amniotic membrane transplantation, autologous limbal cell transplantation, and allogeneic
limbal cell transplantation. However, in patients with bilateral total limbal insufficiency,
there are no autologous limbal cells in the contralateral eye, and allografts may also have
rejection and infection.
Cultured oral mucosa epithelium transplant is a method for treating bilateral full-limbal
cell defects. The patient's own oral mucosal cells are cultured in the laboratory, and the
cultured epithelium is transplanted to the patient's limbus. In the experiment, mouse cells
are used as a feeder cell and transplanted to the human body, which is prone to potential
problems such as rejection or infection. In order to resolve these problems, our laboratory
modified the process of separating the limbal stem cells. By replacing the dispase
II/trypsin-EDTA with Collagenase A, there were no needs to use a feeder cell. This experiment
has been successfully completed under the national plan.
In this study, we want to investigate the cells on the ocular surface form the four patients
who underwent corneal transplantation after receiving CA-COMET.
Dr.Kuan-Ting Kuo, a pathologist in NTUH, will assist us in the staining of the specimens of
the cornea from four patients who underwent corneal transplantation after receiving CA-COMET.
The specimens of the four patients will be stained (Immunohistochemistry) with markers of the
cornea and conjunctival cells (K3, K4, K12, K13, K19, MUC5, P63).
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03674892 -
Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain
|
N/A | |
| Recruiting |
NCT04439552 -
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
|
||
| Not yet recruiting |
NCT04122651 -
Toric Intraocular Lenses for Cataract Patients in the NHS
|
N/A | |
| Recruiting |
NCT03299530 -
Accuracy of Corneal Astigmatism in Different Region Modes
|
||
| Completed |
NCT04560790 -
Safety and Efficacy of CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy to Treat Refractory Viral Keratitis
|
N/A | |
| Recruiting |
NCT03010748 -
Multi-center Clinical Trial on Corneal Morphology Analysis in Chinese Population
|
||
| Completed |
NCT02293122 -
To Investigate Agreement Between the EM-3000 and the Predicate Device Noncon Robo Pachy (F&A) (CellChek XL)
|
||
| Active, not recruiting |
NCT06389916 -
Euclid Phoenix Lens Design Trial
|
N/A | |
| Completed |
NCT06353776 -
MicroPulse Transscleral Laser Therapy and Its Short-term Impact on Ocular Surface
|
N/A | |
| Completed |
NCT03906513 -
Evaluation of the Efficacy of OMK2 in Recovering Corneal Neural Damage in Patients With Diabetes
|
N/A | |
| Not yet recruiting |
NCT06392607 -
Euclid Phoenix Lens Design Trial 2
|
N/A | |
| Recruiting |
NCT05232539 -
Efficiency of Intraoperative Optical Coherence Tomography (iOCT)
|
N/A | |
| Completed |
NCT02781948 -
Evaluation of the Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping With iVue SD-OCT
|
N/A | |
| Not yet recruiting |
NCT05345652 -
Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography
|
||
| Completed |
NCT04804592 -
Investigation in Corneal Sensation and Contact Lens Wear
|
N/A | |
| Recruiting |
NCT04626583 -
Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells
|
Phase 1 | |
| Recruiting |
NCT04323358 -
Agreement and Accuracy of Different Devices for Biometry Measurements in Patients With Cataract
|
N/A | |
| Completed |
NCT06277349 -
Multifocal-toric IOL Compared to Multifocal IOL Combined With Limbal Relaxing Incisions for Correction of Moderate Astigmatism During Cataract Surgery
|
N/A | |
| Withdrawn |
NCT02395952 -
Healing of Persistent Epithelial Defects
|
N/A | |
| Completed |
NCT03518775 -
Repeatability and Reproducibility of the IOLMaster 700 Vers 1.70 and Agreement With IOLMaster 700 Vers. 1.50 and Pentacam
|