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NCT01801722 Clinical Trial

Using NT-proBNP to Detect Chronic Heart Failure in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease Clinical Trial

— NT-proBNP  

Official title:
Using NT-proBNP to Detect Chronic Heart Failure in Patients With Chronic Obstructive Pulmonary Disease.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01801722
Other study ID # 502008
Secondary ID DN50/2008
Status Completed
Phase N/A
First received February 25, 2013
Last updated March 6, 2018
Start date April 2008
Est. completion date June 2008

Study information
Verified date March 2018
Source Lund University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of the present study was to evaluate if the analysis of NT-proBNP might be used as an initial step for the diagnosis of chronic heart failure in patients with COPD in primary health care, and to select patients for a further examination by echocardiography.

Description:

Patients with a confirmed diagnosis of COPD were examined regarding chronic heart failure.

1. An interview regarding symptoms: breathlessness, orthopnoea, night cough, nocturia, walking distance.

2. Physical examination: weight and height, heart and lung auscultation, blood pressure measurement after 5 minutes' rest in the sitting position and the presence of peripheral oedema.

3. Electrocardiography.

4. Natriuretic peptide- NT-proBNP (Immulite 2500, Siemens Healthcare Diagnostics AB Sweden).

5. Patients with the NT-proBNP level of > 1200 pg/ml were referred for echocardiography to assess left ventricular function.

Recruitment information / eligibility
Status Completed
Enrollment 75
Est. completion date June 2008
Est. primary completion date June 2008
Accepts healthy volunteers No
Gender All
Age group 65 Years and older
Eligibility Inclusion Criteria:

- Patients aged 65 years and older with the following diagnosis codes according to International Statistical Classification of Diseases and Related Health Problems - Tenth Revision:J44 (COPD) and J41, J42 (chronic bronchitis) registered during the period 1 January 2008-16 April 2008 according to the electronic patient record.

Exclusion Criteria:

- Impaired cognitive function and/or anticipated difficulties in carrying out spirometry due to immobility,

- psychiatric disorders or terminal illness.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Sweden Primary health care center. Olofström Blekinge

Sponsors (1)
Lead Sponsor Collaborator
Lund University

Country where clinical trial is conducted

Sweden, 

Outcome
Type Measure Description Time frame Safety issue
Primary Percentage of patients with elevated NT-proBNP. NT-proBNP has taken only once in each patient without follow up follow up. Three months was a period when we collected data from all participants. 3 months
Secondary Percentage of patients with abnormal left ventricular function assessed by echocardiography. Association between elevated NT-proBNP and symptoms, signs and electrocardiography. Echocardiography was performed once in each referred patient. Three months was a period of data collection. 3 months
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