Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients

COPD Patients Clinical Trial

— Hyperinflation  

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01475812
• Other study ID #: 0353/03
• Status: Completed
• Phase: N/A
• First received: November 17, 2011
• Last updated: November 18, 2011
• Start date: March 2007

Study information

• Verified date: November 2011
• Source: Federal University of São Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Observational

Clinical Trial Summary

Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)

• clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

Exclusion Criteria:

• Inability to perform the slow vital capacity maneuver

• excessive perceived dyspnea during the test

• arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation

Study Design

Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Activities of Daily Livin.
• COPD Patients
• Dynamic Lung Hyperinflation
• Pulmonary Disease, Chronic Obstructive

Intervention

Other:
• Hyperinflation and ADL
Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.

Locations

Country	Name	City	State
Brazil	Federal University of São Paulo	São Paulo	São Paulo/SP

Sponsors (1)

Lead Sponsor	Collaborator
Federal University of São Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients.		3 months	No