COPD Exacerbation Acute Clinical Trial
Official title:
Role of A. Lumbricoides in the Development of Pulmonary Aspergillosis in Chronic Obstructive Pulmonary Disease Patients
NCT number | NCT05783544 |
Other study ID # | 01032023 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | May 1, 2015 |
Est. completion date | December 31, 2025 |
The prevalence of ascariasis in COPD patients with and without concomitant pulmonary aspergillosis and in controls will be determined. To assess the influence of ascaridosis on the development of pulmonary aspergillosis in COPD patients cytokine status of patients will be studied.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 30 Years to 100 Years |
Eligibility | Inclusion Criteria: - COPD patients - COPD patients with aspergillosis - COPD patients with ascariasis - COPD patients with mix-infection - Healthy individuals (controls) Exclusion Criteria: - COPD patients with other autoimmune diseases - COPD patients with oncological diseases - COPD patients with other co-infections |
Country | Name | City | State |
---|---|---|---|
Uzbekistan | Research institute of epidemiology, microbiology and infectious diseases | Tashkent | Uchtepa |
Lead Sponsor | Collaborator |
---|---|
Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan |
Uzbekistan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum interleukin-1B levels in COPD patients and controls | Serum interleukin-1B (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months | |
Primary | Serum interleukin-4 levels in COPD patients and controls | Serum interleukin-4 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months | |
Primary | Serum interleukin-6 levels in COPD patients and controls | Serum interleukin-6 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months | |
Primary | Serum tumor necrosis factor-a levels in COPD patients and controls | Serum tumor necrosis factor-a (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months | |
Primary | Serum interferon-gamma levels in COPD patients and controls | Serum interferon-gamma (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months | |
Primary | Correlation between cytokine status with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis | The correlation between serum interleukin-1B, interleukin-4, interleukin-6, tumor necrosis factor-a and interferon-y levels with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis will be assessed. | up to 12 months | |
Secondary | Rate of ascariasis infestation among COPD patients and controls | The frequency of ascariasis infestation among COPD patients with and without pulmonary aspergillosis, as well as healthy individuals, will be assessed. | up to 12 months |
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