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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05783544
Other study ID # 01032023
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date May 1, 2015
Est. completion date December 31, 2025

Study information

Verified date July 2023
Source Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Contact Abdurakhim Dr Toychiev, PhD
Phone +998901358977
Email abdurahim1988@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The prevalence of ascariasis in COPD patients with and without concomitant pulmonary aspergillosis and in controls will be determined. To assess the influence of ascaridosis on the development of pulmonary aspergillosis in COPD patients cytokine status of patients will be studied.


Recruitment information / eligibility

Status Recruiting
Enrollment 200
Est. completion date December 31, 2025
Est. primary completion date December 31, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 30 Years to 100 Years
Eligibility Inclusion Criteria: - COPD patients - COPD patients with aspergillosis - COPD patients with ascariasis - COPD patients with mix-infection - Healthy individuals (controls) Exclusion Criteria: - COPD patients with other autoimmune diseases - COPD patients with oncological diseases - COPD patients with other co-infections

Study Design


Intervention

Diagnostic Test:
Interleukin-1B
Level of serum interleukin-1B will be detected
Interleukin-4
Level of serum interleukin-4 will be detected
Interleukin-6
Level of serum interleukin-4 will be detected
tumor necrosis factor - a
Level of serum tumor necrosis factor - a will be detected
interferon- gamma
Level of serum interferon- gamma will be detected

Locations

Country Name City State
Uzbekistan Research institute of epidemiology, microbiology and infectious diseases Tashkent Uchtepa

Sponsors (1)

Lead Sponsor Collaborator
Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan

Country where clinical trial is conducted

Uzbekistan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Serum interleukin-1B levels in COPD patients and controls Serum interleukin-1B (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. up to 12 months
Primary Serum interleukin-4 levels in COPD patients and controls Serum interleukin-4 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. up to 12 months
Primary Serum interleukin-6 levels in COPD patients and controls Serum interleukin-6 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. up to 12 months
Primary Serum tumor necrosis factor-a levels in COPD patients and controls Serum tumor necrosis factor-a (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. up to 12 months
Primary Serum interferon-gamma levels in COPD patients and controls Serum interferon-gamma (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. up to 12 months
Primary Correlation between cytokine status with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis The correlation between serum interleukin-1B, interleukin-4, interleukin-6, tumor necrosis factor-a and interferon-y levels with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis will be assessed. up to 12 months
Secondary Rate of ascariasis infestation among COPD patients and controls The frequency of ascariasis infestation among COPD patients with and without pulmonary aspergillosis, as well as healthy individuals, will be assessed. up to 12 months
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