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Nasal High-flow Compared to Non-invasive Ventilation in Treatment of Acute Acidotic Hypercapnic Exacerbation of Chronic Obstructive Pulmonary Disease

COPD Exacerbation Acute Clinical Trial

Official title:
Nasal High-flow Compared to Non-invasive Ventilation in Treatment of Acute Acidotic Hypercapnic Exacerbation of Chronic Obstructive Pulmonary Disease - a Randomized Controlled Noninferiority Trial

Clinical Trial Summary

The ELVIS study compares the nasal high-flow to non-invasive ventilation in treatment of acute acidotic hypercapnic exacerbation of chronic obstructive pulmonary disease.

Clinical Trial Description

The ELVIS study is a prospective, randomized, multi-centre open label trial following a non-inferiority design to compare the nasal high-flow (NHF) to non-invasive ventilation (NIV) in treatment of acute acidotic hypercapnic exacerbation of chronic obstructive pulmonary disease. Accoring to the randomization the patient is treated with NHF or NIV until discharge. A change of device is possible, if switch criteria are fulfiled OR need for intubation criteria are met before 72h (timepoint for primary endpoint). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04881409
Study type Interventional
Source University of Leipzig
Contact Hubert Wirtz
Phone 00493419712601
Email hubert.wirtz@medizin.uni-leipzig.de
Status Recruiting
Phase N/A
Start date May 6, 2021
Completion date October 6, 2024
View Details
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