PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra

Contraception Clinical Trial

— PARIS  

Official title:

An Open-Label, Randomized, Multicenter Trial to Evaluate Continuation Rates, Side Effects and Acceptability of NuvaRing Versus OrthoEvra

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00269620
• Other study ID #: pittirb0503164
• Status: Completed
• Phase: Phase 4
• First received: September 12, 2005
• Last updated: October 20, 2008
• Start date: June 2005
• Est. completion date: December 2006

Study information

• Verified date: October 2008
• Source: University of Pittsburgh
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

This is an open-label prospective, multicenter, randomized trial to compare continuation rates into the fourth cycle of women using either the NuvaRing or OrthoEvra. Five hundred women will be recruited at 9 centers nationwide to be randomly assigned to use either the NuvaRing or OrthoEvra for four months. Women must either be on the pill or have recently stopped the pill and be relatively satisfied with oral contraceptive use to qualify for enrollment. Two visits and two phone calls will be required.

Description:

The present study is designed primarily to compare continuation rates after three months of use of NuvaRing® and OrthoEvra® in women who had been previously using oral contraceptives. The study attempts to evaluate the possible choices for women who are content with their current or recent method of oral combined hormonal contraception but would be considering a change in their method to a non-daily delivery system. Continuation rates should demonstrate the overall acceptance of both methods as women who find that the method is convenient and has few side effects are likely to continue using the method. Sexual functioning is another important aspect to investigate. The Female Sexual Function Index (FSFI) will be administered to participants along with the planned study questionnaires at the enrollment visit and at the final visit. Additionally, this study will compare side effects, the incidence of bacterial vaginosis, and direct measures of acceptability between the two groups. Efficacy over the three-month study period will also be evaluated; however, since both methods are highly effective and the study is relatively short in duration, the study is not designed to be large enough to detect any differences in efficacy.

This open-label, prospective, multicenter, randomized comparative trial will be conducted in approximately 500 women in the United States who are currently or recently have used a combined oral contraceptive and have no past experience using NuvaRing® or OrthoEvra®. Subjects will be enrolled once they have provided informed consent, had a baseline blood pressure and breast and pelvic examinations, and had negative endocervical testing for gonorrhea and chlamydia. Participants will be randomized to use either NuvaRing® or OrthoEvra® for four continuous cycles beginning with the first day of menses following the enrollment visit. Subjects are to contact the research office by phone to confirm that they initiated the method as instructed. The researchers will contact subjects during the second week of the second cycle of study medication. A final visit will occur during the first week of the fourth cycle of study medication (or sooner if the subject requires or requests early discontinuation). An acceptability questionnaire will be administered at the subject's final visit. This questionnaire has been modified from a questionnaire validated in women using NuvaRing®.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 500
• Est. completion date: December 2006
• Est. primary completion date: December 2006
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Currently or recently (within 3 months of enrollment) using oral contraceptives and content with use.

• In good general health with no contraindications to combined hormonal contraceptive use; premenopausal; and willing to be randomly assigned to use the patch or ring for the next 4 cycles.

• Willing to forego the use of vaginal products and anal intercourse for study duration; if heterosexually active, must be with a single partner for at least the past 3 months and not planning a change during study participation.

Exclusion Criteria:

• Known or suspected pregnancy; hypersensitivity to NuvaRing or OrthoEvra; present or use within 2 months of liver-enzyme-inducing medications or St. John's Wort; breastfeeding currently or within 60 days; abortion or delivery of pregnancy at 15 weeks or greater within 49 days; or abortion within 21 days at 14 weeks or less.

• Previous use of patch or ring for contraception; use of an injectable contraceptive within 6 months; use of an investigational drug within 2 months; or planning a pregnancy within 6 months.

• Diagnosis of gonorrhea or chlamydia at screening, or any vaginal or cervical abnormality that would require colposcopy during the course of the study.

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Contraception

Intervention

Drug:
• ethinyl estradiol/etonogestrel vaginal ring
vaginal ring for cyclic use (3 weeks in, 1 week out)
• ethinyl estradiol/norelgestromin transdermal contraceptive
contraceptive patch worn for 7 days and replaced for use for 3 consecutive weeks followed by a one-week patch free interval

Locations

Country	Name	City	State
United States	Johns Hopkins	Baltimore	Maryland
United States	Boston University	Boston	Massachusetts
United States	University of Chicago	Chicago	Illinois
United States	UCLA-Harbor	Los Angeles	California
United States	University of Wisconsin	Madison	Wisconsin
United States	Columbia University	New York	New York
United States	Eastern Virginia Medical School	Norfolk	Virginia
United States	University of Pennsylvania	Philadelphia	Pennsylvania
United States	Magee-Womens Hospital	Pittsburgh	Pennsylvania
United States	Oregon Health Science University	Portland	Oregon

Sponsors (3)

Lead Sponsor	Collaborator
University of Pittsburgh	Magee-Womens Hospital, Organon

Country where clinical trial is conducted

United States, 

References & Publications (1)

Creinin MD, Meyn LA, Borgatta L, Barnhart K, Jensen J, Burke AE, Westhoff C, Gilliam M, Dutton C, Ballagh SA. Multicenter comparison of the contraceptive ring and patch: a randomized controlled trial. Obstet Gynecol. 2008 Feb;111(2 Pt 1):267-77. doi: 10.1 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	continuation into the fourth cycle		four months	No
Secondary	planned continuation after four cycles		four months	No
Secondary	compare side effect rates		four months	Yes
Secondary	compare acceptability		four months	No
Secondary	evaluate changes in sexual functioning as compared to baseline		four months	No
Secondary	compare changes in Nugent's scores (evaluations for bacterial vaginosis [BV])		four months	Yes
Secondary	evaluate contraceptive efficacy		four months	No
Secondary	evaluate number of phone calls and interim visits due to method related problems		four months	No

External Links

•   University of Pittsburgh Center for Family Planning Research website