Other Clinical Trial - Evaluation of Tracheal Pressure During CPAP

Status Completed

Clinical Trial Summary

This trial evaluates tracheal pressure values in intubated intensive care unit patients during continuous positive airway pressure without any ventilatory support, automatic tube compensation and assisted spontaneous breathing.

Clinical Trial Description

Aim of this trial is to investigate if there are any significant differences between airway and tracheal pressure values during continuous positive airway pressure (CPAP) ventilation. For this purpose, a tracheal pressure measurement catheter is inserted into the tracheal tube and the obtained values are compared with the corresponding airway pressure measured on the ventilator. To further evaluate the impact of mild respiratory support automatic tube compensation and assisted spontaneous breathing with 4 cmH2O will be applied and measured pressure values compared as well. We hypothesize that tracheal pressure will be significantly lower than airway pressure values during inspiration, which represents the primary outcome measure. Secondary outcome parameters include comparison of expiratory and mean pressure values of airway and tracheal pressure. Additionally, effects of mild respiratory support will be evaluated as well. Measurement of inspiratory tracheal pressure might allow to calculate the pressure drop between the airway pressure at the Y-piece of the ventilator and the pressure at the trachea. Currently it is not known, if this pressure drop is significant during CPAP, which represents the rationale to perform this pilot study. In a second step it would be possible to determine if the recorded pressure drop can be used as a surrogate parameter for the respiratory drive in terms of a risk assessment for the development of patient self-inflected lung injury. ;

Study Design

Related Conditions & MeSH terms

Continuous Positive Airway Pressure
CPAP Ventilation

Clinical Trial Details

NCT number	NCT05679635
Study type	Interventional
Source	Medical University Innsbruck
Contact
Status	Completed
Phase	N/A
Start date	November 24, 2022
Completion date	May 14, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04306835` - The Impact of CBT-i on CPAP Therapy Use and Drop Outs in OSAS Patients With Insomnia.	N/A
Completed	`NCT03221205` - Effect of CPAP on Myocardial Dysfunction in Type 2 Diabetes Mellitus and Obstructive Sleep Apnea Patients	N/A
Completed	`NCT04500353` - Routine Or Selective Application of a Face Mask for Preterm Infants at Birth: the ROSA Trial	N/A
Terminated	`NCT02999165` - Breastfeeding Infants Receiving Respiratory Support Trial
Active, not recruiting	`NCT06168682` - Nasal CPAP - The Treatment IMpact on Oxygenation in High-risk Patients During Deep Sedation for Endoscopy	N/A
Recruiting	`NCT05369845` - Observance of Continuous Positive Pressure for the Treatment of Obstructive Sleep Apnea Syndrome	N/A
Completed	`NCT01326975` - Effect of Continuous Positive Airway Pressure Delivered by Two Different Modalities on Breathing Pattern in Preterm Infants	N/A
Completed	`NCT01096433` - Circadian Variations of Prostaglandin in Sleep Apnea	N/A
Completed	`NCT03151317` - Effects of a Therapeutic Education Program on Treatment Adherence Among Patients Prescribed At-home CPAP or At-home NIV
Not yet recruiting	`NCT04747535` - Continuous Positive Airway Pressure After Abdominal Surgery	N/A
Completed	`NCT03432390` - Positive Pressure at Induction of Anesthesia in Children	N/A
Active, not recruiting	`NCT01312168` - Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment	N/A
Terminated	`NCT00482040` - Randomized Trial Investigating Four Nasal CPAP Systems in the Management of Apnea of Prematurity	N/A
Terminated	`NCT02168257` - Neotech RAM Cannula Versus Conventional Binasal Prong Continuous Positive Airway Pressure (CPAP) to Treat Respiratory Distress in Low Birth Weight Neonates	N/A
Recruiting	`NCT03169491` - Effect of CPAP and Adenotonsillectomy in Upper Airway Volume of Children With OSAS	N/A
Completed	`NCT01223274` - Delivery Room CPAP in Extremely Low Birth Weight Infants	Phase 1/Phase 2
Completed	`NCT00780923` - Effect of Continuous Positive Airway Pressure Treatment on Inflammation in Patients With Obstructive Sleep Apnea	N/A
Completed	`NCT04186598` - Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema	N/A
Completed	`NCT03782844` - Efficacy of Simple Continuous Positive Airway Pressure on Patients With Obstructive Sleep Apnea	N/A
Recruiting	`NCT02324530` - Evaluation of Continuous Positive Airway Pressure for Tumor Motion Management in Radiotherapy	Phase 2