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Constriction, Pathologic clinical trials

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NCT ID: NCT03287024 Active, not recruiting - Clinical trials for Pulmonary Artery Stenosis

BeGrow Study to Treat Pulmonary Artery (PA) Stenosis in Newborns and Infants

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Objective of the study is to assess safety and performance of the BeGrow Stent System for newborns and infants in pulmonary artery stenosis.

NCT ID: NCT03270384 Active, not recruiting - Urethral Stricture Clinical Trials

Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease

ROBUST-II
Start date: October 25, 2017
Phase: N/A
Study type: Interventional

The study described below is designed to assess the safety and device performance for the drug coated balloon (DCB) for the treatment of urethral stricture.

NCT ID: NCT03220841 Active, not recruiting - Crohn Disease Clinical Trials

Stricture Definition and Treatment (STRIDENT) Drug Therapy Study

STRIDENT
Start date: October 9, 2017
Phase: Phase 4
Study type: Interventional

Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery. Despite the high frequency, associated disability, and cost there are no are no treatment strategies that aim to improve the outcome of this disease complication. The STRIDENT (stricture definition and treatment) studies aim to develop such strategies.

NCT ID: NCT03115983 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis

Start date: July 17, 2017
Phase: N/A
Study type: Interventional

The LimiFlex™ Clinical Trial is a prospective, concurrently controlled, multi-center study to evaluate the safety and effectiveness of decompression and stabilization with the Empirical Spine LimiFlex™ Paraspinous Tension Band compared to decompression and transforaminal lumbar interbody fusion (TLIF) with concomitant posterolateral fusion (PLF) for the treatment of lumbar degenerative spondylolisthesis (Grade I per Meyerding classification) with spinal stenosis. Clinical trial sites will enroll solely LimiFlex subjects or solely TLIF/PLF subjects.

NCT ID: NCT03112980 Active, not recruiting - Clinical trials for Aortic Valve Stenosis

Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality

DEDICATE
Start date: May 10, 2017
Phase: N/A
Study type: Interventional

Randomized controlled, multi-center trial randomizing patients with symptomatic severe aortic stenosis at low to intermediate operative risk of mortality in a 1:1 fashion to transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) to test, whether TAVI is non-inferior to SAVR, as measured by all-cause mortality or stroke after 1 and 5 years.

NCT ID: NCT03094143 Active, not recruiting - Clinical trials for Aortic Valve Stenosis

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS

EVoLVeD
Start date: July 21, 2017
Phase: N/A
Study type: Interventional

Aortic stenosis is the most common valvular disease in the Western world. It is caused by progressive narrowing of the aortic valve leading to increased strain on the heart muscle which has to work increasingly hard to pump blood through the narrowed valve. Over time the heart muscle thickens to generate more force, but eventually the heart fails leading to death if the valve is not replaced with an operation. No medical treatments exist to stop or reverse the heart valve narrowing. Current clinical guidelines suggest that an operation should be performed only when symptoms develop or the heart muscle is visibly weak on cardiac ultrasound scanning. However, symptoms can be difficult to interpret and in many patients the heart muscle has become irreversibly damaged and the heart fails to recover following surgery. Using MRI scans of the heart, the investigators have identified heart scarring which seems to develop as the heart muscle thickens. Several studies now show that people who have developed this scarring are more likely to suffer poor outcomes including death. The investigators have also identified clinical risks that predict the presence of scarring. The investigators propose a study where patients with severe aortic stenosis but no indications for valve replacement as per current guidelines are assessed for those clinical risks. If a participant's risk of having scarring is higher they will undergo a cardiac MRI scan. If scarring is present participants will be randomised to routine clinical care, or referral for valve replacement surgery. Participants with no evidence of scarring will be randomised routine care with study follow or not. The investigators of this study hypothesize that early surgery will lead to fewer complications and reduced risk of death compared to standard care.

NCT ID: NCT03057353 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

Risk Factors for Ligamentum Flavum Hypertrophy in Lumbar Spinal Stenosis Patients

Start date: May 2012
Phase: N/A
Study type: Observational

To measure ligamentum flavum thickness in patients with different nationalities, sexes, heights, ages, and weights from Xinjiang Uygur Autonomous Region of China with CT, explore the correlation between various factors and ligamentum flavum thickness, provide reference for pedicle screw placement and lumbar decompression surgery, develop individualized surgical programs, and can effectively reduce the incidence of unnecessary postoperative complications induced by misplacement.

NCT ID: NCT03042104 Active, not recruiting - Heart Diseases Clinical Trials

EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis

EARLY TAVR
Start date: July 12, 2017
Phase: N/A
Study type: Interventional

This study will evaluate the safety and effectiveness of the Edwards SAPIEN 3/SAPIEN 3 Ultra Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis.

NCT ID: NCT02903420 Active, not recruiting - Aortic Stenosis Clinical Trials

A Clinical Trial of Transcatheter Aortic Valves in Dialysis Patients (Japan)

Start date: September 2016
Phase: N/A
Study type: Interventional

A single arm, prospective, open, non-randomized, Japanese multicenter trial to evaluate the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve System (Model: 9600TFX) in the treatment of symptomatic severe aortic stenosis patients on chronic dialysis, who are determined by the heart team to be unable to undergo safe open surgical therapy and have the benefits of the study valve implantation. Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.

NCT ID: NCT02825134 Active, not recruiting - Clinical trials for Cardiovascular Diseases

Comparison of TAVR With SAVR in Younger Low Surgical Risk Patients With Severe Aortic Stenosis

NOTION-2
Start date: June 30, 2016
Phase: N/A
Study type: Interventional

A randomized clinical trial investigating transcatheter (TAVR) versus surgical (SAVR) aortic valve replacement in patients 75 years of age or younger suffering from severe aortic valve stenosis. Study hypothesis: The clinical outcome (death of any cause, stroke and rehospitalization (related to the procedure, valve or heart failure)) obtained within one year after TAVR is non-inferior to SAVR.