Constipation Clinical Trial
Official title:
The Intestinal Function in People With Prader-Willi Syndrome
The projects aim is to investigate the intestinal function of patients suffering from Prader-Willi Syndrome. The methods used are ultrasonographic measurement of the rectal diameter and gastrointestinal transit time
Prader-Willi Syndrome (PWS) is a congenital genetical disease characterized by moderate
retardation, food-seeking behavior and a serious risk of developing health threatening
overweight, low stature, abnormal body composition and a lack of growth- and sex-hormones.
They can not live an independent life and are reliant of help from care personnel.
People with PWS react abnormally to signals from their own bodies. E.g. they have a reduced
sense of pain and can have a lacking urge to urination despite a full bladder. Most of the
patients also have a relatively slow pulse, which can be consistent with a dysfunction in
the nervous system (the parasympathetic nervous system) which also has large significance
for the bladder- and bowel function.
The Intestinal function in people with PWS is a sparse described subject, which has not been
systematically examined in scientific context. We therefore want to examine whether the
bowel function in people with PWS are different from the bowel function in healthy people.
The subject is elucidated by a medical examination, a questionnaire, a registration of
toilet habits, a measurement of the rectal diameter by an ultrasound scan and a measurement
of the colonic transit time.
The results will be compared to findings in normal healthy people. Because no normal
material exists for rectal diameter measured by ultrasound, we will establish one.
The result of the project will increase our knowledge of possible bowel dysfunctions such as
constipation, in people with PWS and can immediately lead to improved care for and optimized
treatment of the patients.
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Observational Model: Case Control
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