Esketamine Clinical Trial
Official title:
Effect of Esketamine on Conscious State in Patients With Prolonged Disorders of Consciousness#a Prospective, Randomized, Exploratory Study
The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia. Participants will be patients with prolonged disorders of consciousness undergoing surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg/kg esketamine or saline will be infused will be infused intravenously at a constant speed within 30 min after tracheal intubation/pneumatectomy fixation. Coma recovery scale-revised, Glasgow coma scale, Full Outline of UnResponsiveness scores, SedLine multi-channel electroencephalogram and perioperative adverse events after surgery will be investigated.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05506787 -
The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Disease
|
Phase 4 | |
| Not yet recruiting |
NCT06062550 -
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
|
Phase 4 | |
| Recruiting |
NCT06003218 -
Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation
|
N/A | |
| Recruiting |
NCT04664530 -
The Study on the Esketamine in the Treatment of Postherpetic Neuralgia
|
Phase 4 | |
| Not yet recruiting |
NCT06117917 -
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05718024 -
Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality With Mechanical Ventilation
|
Phase 4 | |
| Recruiting |
NCT05950646 -
Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality
|
Phase 4 | |
| Recruiting |
NCT05732064 -
Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality
|
Phase 4 | |
| Not yet recruiting |
NCT06399185 -
Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort
|
Phase 4 | |
| Recruiting |
NCT04860661 -
Esketamine on Postpartum Depression in Cesarean Section Women
|
N/A | |
| Completed |
NCT06398834 -
Esketamine and Butorphanol for Post-Lobectomy Pain
|
Phase 4 | |
| Completed |
NCT05458453 -
An Exploratory Study of Esketamine in Patients After Thoracoscopic Surgery
|
Phase 4 | |
| Recruiting |
NCT04843982 -
Immunoinflammatory Regulation of Esketamine in Septic Patients
|
Phase 4 | |
| Not yet recruiting |
NCT05943028 -
Effect of Subanesthetic Dose Esketamine on Propofol-refentanil Closed-loop Targeted Controlled Infusion
|
Early Phase 1 | |
| Active, not recruiting |
NCT05718544 -
Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes
|
Phase 4 | |
| Not yet recruiting |
NCT06087510 -
Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes
|
Phase 4 | |
| Recruiting |
NCT06051227 -
Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial
|
Phase 3 | |
| Recruiting |
NCT04425473 -
Esketamine and Perioperative Depressive Symptoms
|
Phase 2/Phase 3 | |
| Completed |
NCT05096468 -
Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms.
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT04777110 -
The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy
|
Early Phase 1 |