Effect of Esketamine on Conscious State in Patients With pDoC

Status Not yet recruiting

Clinical Trial Summary

The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia. Participants will be patients with prolonged disorders of consciousness undergoing surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg/kg esketamine or saline will be infused will be infused intravenously at a constant speed within 30 min after tracheal intubation/pneumatectomy fixation. Coma recovery scale-revised, Glasgow coma scale, Full Outline of UnResponsiveness scores, SedLine multi-channel electroencephalogram and perioperative adverse events after surgery will be investigated.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06389344
Study type	Interventional
Source	Beijing Tiantan Hospital
Contact	Ruquan Han, M.D
Phone	8610-59976660
Email	ruquan.han@ccmu.edu.cn
Status	Not yet recruiting
Phase	N/A
Start date	May 1, 2024
Completion date	June 30, 2026

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