Connective Tissue Diseases Clinical Trial
Official title:
Early Detection of Cardiac Impairment and Prediction of Right Ventricular Hypertrophy in Patients With Connective Tissue Disease
There have been reports suggesting that progressive RV failure and death in connective tissue disease (CTD) are related to right ventricular hypertrophy (RVH) and dilation, irrespective of pulmonary arterial hypertension (PAH). The investigators aim to identify cardiac markers that occur before RVH and to investigate predictors of RVH.
Patients with connective tissue disease (CTD) frequently exhibit multi-organ
pathophysiological and functional damage. The heart, one of the leading causes of CTD
mortality, has attracted increasing attention. However, most patients with CTD present with
nonspecific cardiac symptoms, normal ECG, and preserved left ventricular ejection fraction
(LVEF) and therefore do not receive an early cardiac diagnosis. Pulmonary arterial
hypertension (PAH), right ventricular (RV) dilatation and hypertrophy are the first and the
most frequent cardiac findings. However, these are late-stage phenomena, which can eventually
lead to death or right heart failure in CTD.Right ventricle abnormalities is associated with
the risk of heart failure and cardiovascular death. RV dilation has long been considered a
direct consequence of pulmonary arterial hypertension (PAH), but recently, physicians have
observed RVH in CTD patients as well. RV dilation and RVH are not necessarily found in the
same patient. The pathophysiology behind these issues is less well-understood. RVH
progression continues even as CTD-associated PAH alleviates. This finding implies PAH might
not be the sole index that leads to RVH. It would be interesting to explore factors that can
predict the presence of RVH, which may reduce major adversecardiovascular events in patients
with CTD.
Cardiovascular magnetic resonance (CMR) is able to depict myocardial characteristics from
structure to tissue properties using cine and late gadolinium enhancement (LGE) sequences.
Newly developed imaging studies to date include T1 mapping and T1-derived Manuscript ECV
estimation.All the previous studies in CTD have been restricted to patients with advanced
cardiac involvement. Together with clinical assessment and multi-imaging tests, the aim of
the present study was to find markers to detect cardiac involvement before RVH presented,
which could be important for guiding treatment decisions such as the timing and choice of
pharmaceutical treatment. The combination of myocardial functional and tissue changes may
offer further insight into the pathophysiology of CTD.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04169100 -
Novel Form of Acquired Long QT Syndrome
|
Phase 4 | |
Enrolling by invitation |
NCT03683186 -
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
|
Phase 3 | |
Active, not recruiting |
NCT03688191 -
Study of Sirolimus in CTD-TP in China
|
Phase 4 | |
Completed |
NCT00004357 -
Absorption of Corticosteroids in Children With Juvenile Dermatomyositis
|
Phase 2 | |
Recruiting |
NCT04918524 -
The Clinical Features and Pregnancy Outcomes of CTD Patients
|
||
Recruiting |
NCT04993885 -
Avatrombopag in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies
|
Phase 2 | |
Not yet recruiting |
NCT05998759 -
Telitacicept for the Treatment of Connective Tissue Disease-associated Thrombocytopenia
|
Phase 2 | |
Recruiting |
NCT05065814 -
Connective Tissue Diseases and Vitamin D Deficiency
|
N/A | |
Completed |
NCT03494036 -
Effect of Synbiotic on Immune Response, Gut Permeability and Microbiota in Patient With Connective Tissue Disease
|
N/A | |
Completed |
NCT03929120 -
Allogeneic Bone Marrow Mesenchymal Stem Cells for Patients With Interstitial Lung Disease (ILD) & Connective Tissue Disorders (CTD)
|
Phase 1 | |
Completed |
NCT00001330 -
Study of Silicone-Associated Connective Tissue Diseases
|
N/A | |
Not yet recruiting |
NCT05980728 -
Connective Tissue Disease Patients With Pulmonary Hypertension
|
||
Not yet recruiting |
NCT04582292 -
Laryngeal Manifestations of Connective Tissue Diseases
|
||
Completed |
NCT06458803 -
Efficacy and Safety of Eltrombopag for Refractory Thrombocytopenia Associated With Connective Tissue Disease
|
||
Recruiting |
NCT03214263 -
Identification of New Biomarkers to Promote Personalized Treatment of Patients With Inflammatory Rheumatic Diseases
|
||
Completed |
NCT04171362 -
The Effect of Connective Tissue Massage in Patients With Migraine
|
N/A | |
Completed |
NCT02392130 -
A Clinical Trial to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin
|
Phase 1 | |
Completed |
NCT01656278 -
An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis
|
N/A | |
Recruiting |
NCT04915482 -
TPO-RAs Combined With Anti-CD20 Antibody in the Treatment of Adult Immune Thrombocytopenia With Autoantibodies
|
Phase 2/Phase 3 | |
Recruiting |
NCT05505409 -
Efficacy and Safety of Pirfenidone in CTD-ILD
|
Phase 4 |