Interstitial Lung Disease Clinical Trial
Official title:
Efficacy, Safety, Immune Function of Pirfenidone in the Treatment of Connetive Tissue Disease -Related Interstitial Lung Disease(CTD-LID)
A single-center randomized controlled study will be used to observe the efficacy and safety of pirfenidone on CTD-ILD patients for 24 months. The main research endpoints is the lung function (FVC) at 6 months. The clinical dyspnea score, 6-minute walking distance, index of lung function and imaging indicators are evaluated, as well as primary disease activity and adverse reactions of therapy with glucocorticoid and immunosuppressants up to 24 months.
A total of 120 Chinese patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), including inflammatory myopathy (IIM), rheumatoid arthritis (RA), systemic sclerosis (SSc), and other connective tissue diseases, will be enrolled to use Pirfenidone or not in this study according to 2:1 random entry. Glucocorticoid and immunosuppressants worked as background treatment. The main research endpoint is the lung function (FVC) at 6 months. The clinical dyspnea score, 6-minute walking distance, lung function and imaging indicators, primary disease activity index are evaluated regularly until 24 months. The relationship of pirfenidone concentration, clinical effect and safety, immune function will be analyzed also. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT04905693 -
Extension Study of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis
|
Phase 3 | |
| Recruiting |
NCT05631132 -
May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?
|
N/A | |
| Recruiting |
NCT05417776 -
Collagen-targeted PET Imaging for Early Interstitial Lung Disease
|
Phase 2 | |
| Not yet recruiting |
NCT04089826 -
Long Term Oxygen Therapy in Patients With Interstitial Lung Disease
|
||
| Recruiting |
NCT03467880 -
Multicenter Study of Impulse Oscillometry in Chinese
|
N/A | |
| Completed |
NCT00883129 -
Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)
|
Phase 2 | |
| Completed |
NCT00362739 -
Blood Collection From Individuals With Lung Disease for Genetic Studies
|
N/A | |
| Recruiting |
NCT06133998 -
Effects of Incentive Spirometry With and Without Aerobic Exercises in Interstitial Lung Disease
|
N/A | |
| Active, not recruiting |
NCT03485378 -
Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease
|
N/A | |
| Recruiting |
NCT04098094 -
Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
|
||
| Recruiting |
NCT03400839 -
Best Clinical Endpoints That Likely Induce Worse Prognosis in Interstitial Lung Diseases
|
||
| Terminated |
NCT02633293 -
An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE
|
Phase 2/Phase 3 | |
| Enrolling by invitation |
NCT05001009 -
Goals of Care Conversations Study
|
N/A | |
| Active, not recruiting |
NCT05068869 -
Digital Outpatient Services
|
N/A | |
| Active, not recruiting |
NCT03727568 -
Study Comparing Two Different Methods of Cryobiopsy in the Interstitial Lung Diseases
|
N/A | |
| Recruiting |
NCT06046547 -
Integrating Palliative Care Education in Pulmonary Rehabilitation
|
N/A | |
| Completed |
NCT04946708 -
Virtual Exercise Program in Interstitial Lung Disease (ILD) Patients
|
N/A | |
| Recruiting |
NCT04139356 -
The Effect of Spontaneous Respiration on Pulse-oximetry Measurements
|
N/A | |
| Recruiting |
NCT03726398 -
CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PH
|
Phase 2/Phase 3 | |
| Active, not recruiting |
NCT03295279 -
WTC Chest CT Imaging Archive
|