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The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults

Congenital Heart Disease Clinical Trial

Official title:
Exploring the Relationship Between Advanced Multimodal Brain MRI Phenotypes, Genes and Cognitive Outcome in Adults With CHD

Clinical Trial Summary

The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).

Clinical Trial Description

Aim 1 is structured to determine the relationship between sulcal patterns(measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2 or ε4 alleles, or (b) damaging variants in hypoxia response genes. Aim 2 is designed to determine the relationship between structural connectivity using rich club (measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2 or ε4 alleles or (b) damaging variants in hypoxia response genes. In Aim 3, the investigators will determine the relationship between functional connectivity using rich club (measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2or ε4 alleles or (b) damaging variants in hypoxia response genes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05258981
Study type Interventional
Source Boston Children's Hospital
Contact Michelle Gurvitz, MD
Phone 617-355-6508
Email michelle.gurvitz@cardio.chboston.org
Status Recruiting
Phase N/A
Start date July 1, 2022
Completion date June 2026
View Details
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