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Myocardial FIbrosis in Repaired Tetralogy of FAllot- FIFA Study) — FIFA  

Congenital Heart Disease Clinical Trial

Official title:
Interstitial Myocardial Fibrosis in Repaired Tetralogy of Fallot: Assessment by Molecular and Imaging Biomarkers and Association With Adverse Events ( Myocardial FIbrosis in Repaired Tetralogy of FAllot- FIFA Study)

Clinical Trial Summary

This study aims to study the correlation between biomarkers of myocardial fibrosis (extracellular volume fraction calculated by cardiac magnetic resonance imaging (MRI) (T1-mapping) and levels of molecular biomarkers of fibrosis) and adverse events in a population of patients with repaired tetralogy of Fallot.

Clinical Trial Description

The main causes of mortality in adults with repaired tetralogy of Fallot (TF) are sudden death and heart failure. Myocardial fibrosis has been linked to the appearance of arrhythmias and ventricular dysfunction in other patient populations, but this association is poorly studied in patients with TF, perhaps because research in congenital heart disease (CHD) requires multicenter studies, difficult to carry out. Interstitial myocardial fibrosis assessed by molecular and imaging biomarkers is associated with adverse events in patients with repaired Fallot tetralogy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04737135
Study type Observational [Patient Registry]
Source Hospital Universitari Vall d'Hebron Research Institute
Contact Laura Dos Subirá, MD, PhD
Phone +34932746170
Email ldos@vhebron.net
Status Recruiting
Phase
Start date July 9, 2018
Completion date June 30, 2022
View Details
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