Congenital Heart Disease Clinical Trial
Official title:
Utility of Lung Ultrasound in the Estimation of Extravascular Lung Water in Pediatric Population- a Prospective Observational Study
Increased extravascular lung water (EVLW) may increase mortality and morbidity in
cardiopulmonary pathology. Many factors can cause increased extravascular lung water and
pulmonary edema after cardiac surgery. This includes left ventricular failure, acute mitral
regurgitation; systemic inflammatory response post-cardiopulmonary bypass, left to right
shunts, transfusion associated acute lung injury, acute respiratory distress syndrome(ARDS)
and sepsis.
The clinical assessment of lung water ranges from auscultation to radiological methods to
invasive measurements like dye dilution or thermodilution studies.
Lung ultrasonography is the newest modality for noninvasive assessment of extravascular lung
water. Lung ultrasound has been validated against auscultation, chest X-rays, CT chest as
well as the bedside gold standard, transpulmonary thermodilution in adults.
Critically ill children are more susceptible to complications and worsened outcomes from
increased EVLW.
Lung ultrasound correlates with clinical and radiological endpoints, but has not been
validated against invasive objective measures like transpulmonary thermodilution.
Evaluation of transpulmonary thermodilution setups in the pediatric population has shown
different normal values and cutoffs compared to adults, possibly due to differential rates
growth and development.
It is aimed to investigate the correlation of Lung ultrasound based indices of extravascular
lung water to invasive measures, assess optimum cutoffs to appropriate clinical endpoints and
evaluate their sensitivity and specificity.
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