PREVENTION-ACHD Risk Score

Congenital Heart Disease Clinical Trial

— PREVENTIONACHD  

Official title:

PRospEctiVE Study on implaNTable cardIOverter Defibrillator Therapy and SuddeN Cardiac Death in Adults With Congenital Heart Defects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03957824
• Other study ID #: 2014_248#C20141535
• Status: Completed
• Start date: January 1, 2015
• Est. completion date: June 30, 2018

Study information

• Verified date: May 2019
• Source: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Sudden cardiac death (SCD) is one of the major causes of mortality in adults with congenital heart disease (ACHD). Risk stratification for sudden cardiac death in this patient group is challenging and at the current moment there are no clear guidelines on implantable cardioverter-defibrillator (ICD) implantation for primary prevention of SCD in this young patient population. The reason for this is the fact that this is a heterogenous group of patients and SCD is a relatively rare event. Because of this there have been no prospective studies on SCD in ACHD. However, multiple retrospective studies on ICD implantation in ACHD have shown that this treatment does appear to be effective. Researchers from the Academic Medical Center have identified several risk factors for sudden cardiac death. A risk score was created using this data, which has been validated in an internal and external cohort in a retrospective setting. The design of this study, including the conception of the risk score, its calculation method and validation will be published in an international scientific peer-reviewed journal.

The hypothesis of this study is that the risk score accurately predicts the risk of sudden cardiac death.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 783
• Est. completion date: June 30, 2018
• Est. primary completion date: December 31, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• adult (=18 years old) patient with a diagnosis of a congenital heart defect.

Exclusion Criteria:

• Patients of whom follow up is not possible, e.g. no permanent home address, living outside of or expecting to move out of the area wherein travelling to the investigating hospital outpatient clinic is possible.

• Patients with documented sustained ventricular tachycardia or ventricular fibrillation.

• Patients for whom the risk is not calculable because of a congenital heart disease diagnose not represented in the risk score.

• Patients for whom the risk score is not calculable because of missing data

• Patients with recent (<3 months ago) myocardial infarction.

• Patients in whom the high SCD-risk status depends on an impaired ejection fraction that is expected to improve, e.g. due to tachycardiomyopathy.

• Patients with a guideline defined contraindication for ICD implantation.

Related Conditions & MeSH terms

• Congenital Heart Disease
• Death
• Death, Sudden
• Death, Sudden, Cardiac
• Heart Diseases
• Tachycardia
• Tachycardia, Ventricular
• Ventricular Fibrillation
• Ventricular Tachycardia

Intervention

Diagnostic Test:
• PREVENTION-ACHD risk score
The predicted risk of sudden cardiac death according to a risk score will be tested by the actual rate of sudden cardiac death

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sudden cardiac death and ventricular fibrillation or sustained ventricular tachycardia	The rate of sudden cardiac death and ventricular fibrillation or sustained ventricular tachycardia in adult congenital heart disease patients	2 years
Secondary	Sudden cardiac death	The rate of sudden cardiac death in adult congenital heart disease patients	2 years