Congenital Heart Disease Clinical Trial
Official title:
Evaluation of the Systemic Microcirculation in the Course of Cardiopulmonary Bypass Used in the Surgery for Repair of Congenital Heart Defects in Infants and Children
General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
• Specific objectives:
- To test the usefulness of skin laser Doppler flowmetry monitoring (LDPM) in the
non-invasive evaluation of endothelium-dependent microvascular reactivity during CPB in
children.
- To investigate whether skin LDPM could be proposed as a clinical monitoring of tissue
perfusion during CPB in pediatric cardiac surgery.
- To investigate the effects of different anesthetic agents on microvascular reactivity
during CPB.
- To investigate the effects of cardiovascular and vasoactive drugs used during CPB on
microvascular reactivity.
- To evaluate the correlation of microcirculatory alterations observed during CPB with
classical markers of tissue perfusion and oxygenation, including plasma lactate levels.
- To evaluate the correlation of microcirculatory alterations observed during CPB with
markers of systemic inflammation, including pro- and anti-inflammatory cytokines.
- To evaluate the correlation of microcirculatory alterations observed during CPB with the
plasma bioavailability of nitric oxide.
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