Congenital Heart Disease Clinical Trial
Official title:
Combined Echocardiographic and MRI Assessment of Diastolic Function in Patients With Congenital Heart Disease
Diastolic function is poorly studied in children with congenital heart disease. This is
mainly due to the lack of validated techniques. Cardiac MRI offers two advantages compared
to echocardiography: 1. accurate measurements of ventricular volumes and mass; 2. tissue
characterization. The main advantage of echocardiography is a better temporal resolution
which allows the study of short events like early relaxation. Overall there is a lack of
studies correlating different echocardiographic and MRI parameters of heart function in
pediatric populations with congenital or acquired heart diseases. This study will address
specific questions on specific groups of patients that might bring more insight into chamber
interaction and cardiac function. This study hypothesizes the following:
- Atrial enlargement is a marker of chronic increase in filling pressures and 3D echo
might be the best method for follow-up.
- Cardiac remodeling associated with chronic loading results in changes in diastolic
properties related to changes in cardiac mass and volume. This is related to changes in
cardiac mechanics influencing diastolic parameters. Especially the influence on
twisting and untwisting will be studied.
- Regional myocardial fibrosis and scarring may account for regional systolic and
diastolic dysfunction with possible prognostic impact
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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