Congenital Heart Disease Clinical Trial
Official title:
Standard vs. Washed Blood Cell Transfusions in Pediatric Cardiac Surgery: Impact on Post-operative Inflammation as Evidenced by the IL-6 to IL-10 Ratio.
Background: Children having open heart surgery to repair congenital heart defects demonstrate
a large inflammatory response to the heart-lung machine and to surgery itself. In general,
the more intense their inflammatory response, the more critically ill they are following
surgery. These children routinely require large numbers of blood transfusions during and
following surgery as part of their medical management that adds to their heightened
inflammatory state. Whether additional steps to "wash" blood products and remove the
substances contributing to post-transfusion inflammation will limit this response, and
improve the health of children following open heart surgery, remains to be studied.
Aims: To compare the inflammatory response in children having open heart surgery who receive
washed versus unwashed blood transfusions.
Methods: We will randomly assign children having open heart surgery to one of two groups:
group 1 will receive blood transfusions per the current standard of care, group 2 will
receive blood transfusions that have been washed in addition to the current standard of care.
We will then use blood tests to measure the inflammatory response in children of each group.
We will compare the results to determine whether washing blood transfusions decreases
inflammation and post-operative complications following open heart surgery.
Conclusion: We believe that washing blood transfusions given to children following open heart
surgery will decrease their inflammatory response and improve their overall health.
n/a
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