Airway Inflammation in Congenital Diaphragmatic Hernia Patients

Status Completed

Clinical Trial Summary

We propose to examine Congenital Diaphragmatic Hernia (CDH) patients for evidence of airway inflammation as a first step to characterize the reported bronchodilator responsiveness. Airway biopsy studies are invasive and thus we propose to perform induced sputum studies to document the amount and type of inflammation present. Another ancillary non-invasive measure of airway inflammation that we will use is exhaled nitric oxide (NO). The primary objective of this study is to determine if CDH patients have any evidence of airway inflammation. The hypothesis of this study is that children with CDH do not have evidence of airway inflammation associated with bronchodilator responsiveness. Based on this information, treatment for CDH patients will hopefully be more accurate and appropriate for their specific needs.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02453750
Study type	Interventional
Source	The Hospital for Sick Children
Contact
Status	Completed
Phase	N/A
Start date	February 2012
Completion date	October 2013

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05100693` - Smart Removal for Congenital Diaphragmatic Hernia	N/A
Recruiting	`NCT05450653` - Trial of FETO for Severe Congenital Diaphragmatic Hernia	N/A
Terminated	`NCT04140669` - Automated Myocardial Performance Index Using Samsung HERA W10
Recruiting	`NCT05201144` - A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)	Phase 2
Recruiting	`NCT04429750` - Intact Cord Resuscitation in CDH	N/A
Recruiting	`NCT03750266` - 3D Animation and Models to Aid Management of Fetal CDH
Completed	`NCT01243229` - Genetic Analysis of Congenital Diaphragmatic Disorders
Recruiting	`NCT04583644` - Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)	N/A
Completed	`NCT03314233` - Delayed Cord Clamping for Congenital Diaphragmatic Hernia	N/A
Recruiting	`NCT04114578` - Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia
Completed	`NCT03666767` - Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
Recruiting	`NCT02986087` - Feto-Endoscopic Tracheal Occlusion (FETO) for Left Congenital Diaphragmatic Hernia	N/A
Recruiting	`NCT03674372` - Fetoscopic Endoluminal Tracheal Occlusion	N/A
Active, not recruiting	`NCT05839340` - Neurally Adjusted Ventilatory Assist for Neonates With Congenital Diaphragmatic Hernias	N/A
Enrolling by invitation	`NCT05962346` - Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia	N/A
Withdrawn	`NCT04186039` - Functional Evaluation of the Fetal Lung by Functional Magnetic Resonance Imaging - Blood Oxygenation Level Dependent (MRI-BOLD), in Congenital Diaphragmatic and Parietal Malformations	N/A
Unknown status	`NCT01302977` - Fetal Tracheal Occlusion in Severe Diaphragmatic Hernia: a Randomized Trial	Phase 2
Recruiting	`NCT03179371` - Proteomic Profiling for Congenital Diaphragmatic Hernia
Recruiting	`NCT03138863` - Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO)	N/A
Active, not recruiting	`NCT04484441` - Maternal-fetal Immune Responses to Fetal Surgery