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Congenital Defects clinical trials

View clinical trials related to Congenital Defects.

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NCT ID: NCT00766571 Completed - Clinical trials for Congenital Abnormalities

Clinical and Genetic Studies of VACTERL Association

Start date: September 29, 2008
Phase:
Study type: Observational

This study will explore the medical problems in patients with VACTERL association and identify gene changes that might be responsible for them. VACTERL association can affect many parts of the body, including the bones of the spine, the heart, the lower intestinal tract, the connection between the trachea and esophagus, the kidneys and the arms. Information from this study may lead to a better understanding of the disease and improved treatment and genetic counseling. Patients with VACTERL association and their parents and siblings may be eligible for this study. Patients are admitted to the NIH Clinical Center for evaluation over 3 to 4 days that may include the following procedures: - Physical examination, medical history, electrocardiogram (EKG), blood and urine tests - Eye examination - Imaging studies (echocardiogram, x-rays and ultrasound tests) - Other specialized tests or consultations as indicated - Optional medical photographs of the face and other body parts that may be involved in VACTERL association for publication in scientific texts or for teaching purposes - Optional return visit after 2 years for repeat testing and to look for changes over time Parents of patients have the following procedures: - Physical examination, medical history, blood tests and x-rays, if needed - Specialty consultations as indicated - Optional medical photographs of the face and other body parts that may be involved in VACTERL association for publication in scientific texts or for teaching purposes - Questionnaires about their child s medical history, growth, behavior and development, therapy and medication Siblings of patients have the following procedures: - Physical examination, medical history and blood tests

NCT ID: NCT00469742 Completed - Clinical trials for Cardiopulmonary Bypass

Aprotinin in Neonates Undergoing Cardiopulmonary Bypass

Start date: April 2007
Phase: N/A
Study type: Observational

This is a retrospective chart review study. The purpose of this study is to review our experience at Children's Healthcare of Atlanta in neonates receiving aprotinin. We will examine the specific outcomes of renal dysfunction, thrombosis and mortality.

NCT ID: NCT00097149 Completed - Cleft Palate Clinical Trials

Systematic Pediatric Care for Oral Clefts - South America

Start date: May 2003
Phase: N/A
Study type: Interventional

Cleft lip and palate are a significant component of morbid human birth defects in the developing world. This study measures the impact of having a child born with a cleft lip on subsequent maternal/infant family health, and whether frequent pediatric care compared to standard pediatric care will reduce neonatal mortality in children born with cleft lip and palate.